Periactin and Ms contin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Ms contin (morphine sulfate). Common drug interactions include coagulopathy among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Ms contin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Ms contin?

Ms contin has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 69,289 Ms contin users. Check the latest studies of Ms contin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

17 people who take Periactin and Ms contin together, and have interactions are studied.

Periactin and Ms contin drug interactions.

What are the common drug interactions of Periactin and Ms Contin, by gender? *:

female:

Coagulopathy (blood's ability to clot is impaired)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Irritability
Multi-organ failure (multisystem organ failure)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)
Pruritus (severe itching of the skin)
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Urinary tract infection

male:

Hypotension (abnormally low blood pressure)
Sepsis (a severe blood infection that can lead to organ failure and death)
Haemoglobin decreased
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Knee arthroplasty
Lower respiratory tract infection
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Oedema (fluid collection in tissue)
Pallor
Red blood cell count decreased

What are the common drug interactions of Periactin and Ms Contin, by age (0-1 to 60+)? *:

0-1:

Abdominal compartment syndrome (increased pressure in abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
Blood lactic acid increased
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)
Duodenal perforation (complication of duodenal ulcer)
Enterococcal infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

2-9:

n/a

10-19:

Coagulopathy (blood's ability to clot is impaired)
Multi-organ failure (multisystem organ failure)
Neurological symptom (symptoms of nervous system disease)
Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)
Respiratory failure (inadequate gas exchange by the respiratory system)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Irritability
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Pruritus (severe itching of the skin)
Urinary tract infection
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Chronic kidney disease
Death
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Disbacteriosis (a condition with microbial imbalances on or inside the body)

60+:

Coagulopathy (blood's ability to clot is impaired)
Hypotension (abnormally low blood pressure)
Oedema peripheral (superficial swelling)
Surgery
Swelling face
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 17.65%
Multiple Myeloma (cancer of the plasma cells): 3 people, 17.65%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 17.65%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 11.76%
Pancreatitis (inflammation of pancreas): 2 people, 11.76%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 11.76%
Rickets (softening of bones): 2 people, 11.76%
Back Pain: 1 person, 5.88%
Bleeding Disorders: 1 person, 5.88%
Blood Pressure Abnormal: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Periactin and Ms contin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously