Periactin and Proventil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Periactin (cyproheptadine hydrochloride) and Proventil (albuterol). Common drug interactions include infective pulmonary exacerbation of cystic fibrosis among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Periactin and Proventil. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

What is Proventil?

Proventil has active ingredients of albuterol. It is often used in asthma. eHealthMe is studying from 16,110 Proventil users. Check the latest studies of Proventil.

On Jul, 14, 2026

31 people who take Periactin and Proventil together, and have interactions are studied.

Periactin and Proventil drug interactions.

What are the common drug interactions of Periactin and Proventil, by gender? *:

female:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Back pain
Cellulitis (infection under the skin)
Chills (felling of cold)
Confusional state
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Cystic fibrosis (disease of the secretary glands)
Depression

male:

Pneumonia
Vomiting
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Chronic respiratory failure
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Discomfort
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the common drug interactions of Periactin and Proventil, by age (0-1 to 60+)? *:

0-1:

Acute respiratory failure
Catheter site discharge
Catheter site haemorrhage (bleeding at catheter site)
Catheter site pain
Catheter site swelling
Feeling hot
Flushing (the warm, red condition of human skin)
Infusion site pain
Pyrexia (fever)
Tracheostomy malfunction (a surgical opening of trachea not working normally)

2-9:

Abdominal pain
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Infusion site pain
Pneumonia
Activities of daily living impaired
Bone pain
Chest discomfort
Chest pain
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Conjunctivitis (pink eye)

10-19:

Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Fatigue (feeling of tiredness)
Abdominal distension
Abnormal behaviour
Acute respiratory failure
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Constipation
Cough
Cystic fibrosis (disease of the secretary glands)
Depressed level of consciousness

20-29:

Alopecia (absence of hair from areas of the body)
Chills (felling of cold)
Chronic respiratory failure
Productive cough
Pyrexia (fever)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Upper respiratory tract infection
Abdominal pain
Acute sinusitis
Constipation

30-39:

n/a

40-49:

Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Gait disturbance
Hypertension (high blood pressure)
Ligament sprain (ligament stretched)
Meniscus lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia)
Neuropathy peripheral (surface nerve damage)
Rash
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Skin disorder (skin disease)

50-59:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Irritability
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Pruritus (severe itching of the skin)
Urinary tract infection

60+:

Dizziness
Abdominal pain
Fall
Loss of consciousness
Muscle spasms (muscle contraction)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 10 people, 32.26%
Wheezing (a high-pitched whistling sound made while you breath): 7 people, 22.58%
Cough: 6 people, 19.35%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 5 people, 16.13%
Dyspnea (difficult or laboured breathing): 4 people, 12.90%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 3 people, 9.68%
Constipation: 3 people, 9.68%
Cystic Fibrosis Lung (fibrosis with cyst in the lung): 3 people, 9.68%
High Blood Pressure: 3 people, 9.68%
Kaposi's Sarcoma (a tumour caused by human herpes virus): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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