Peridex and Levothroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Peridex (chlorhexidine gluconate) and Levothroid (levothyroxine sodium). Common drug interactions include meningitis among females and pneumothorax among males.

The phase IV clinical study analyzes what interactions people have when they take Peridex and Levothroid. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Peridex?

Peridex has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 2,803 Peridex users. Check the latest studies of Peridex.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.

On Jul, 05, 2026

17 people who take Peridex and Levothroid together, and have interactions are studied.

Peridex and Levothroid drug interactions.

What are the common drug interactions of Peridex and Levothroid, by gender? *:

female:

Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Nephrolithiasis (calculi in the kidneys)
Osteonecrosis (death of bone)
Renal failure (kidney dysfunction)
Tooth discolouration (a change in colour of teeth)
Tooth disorder (tooth disease)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fall
Mouth ulceration (mouth ulcers)
Pain

male:

Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

What are the common drug interactions of Peridex and Levothroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthropathy
Influenza like illness
Joint injury
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nephropathy (damage to or disease of a kidney)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Adverse event
Anaemia (lack of blood)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
Cytomegalovirus oesophagitis (oesophagus infection with cytomegalo virus)
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Jaw disorder (jaw disease)
Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)

50-59:

Jaw disorder (jaw disease)
Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Nephrolithiasis (calculi in the kidneys)
Osteonecrosis (death of bone)
Renal failure (kidney dysfunction)
Tooth discolouration (a change in colour of teeth)
Tooth disorder (tooth disease)
Adverse event
Anaemia (lack of blood)

60+:

Drug ineffective
Injection site haemorrhage (bleeding from injection site)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 35.29%
Osteoporosis (bones weak and more likely to break): 6 people, 35.29%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 23.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 17.65%
High Blood Pressure: 3 people, 17.65%
Oedema (fluid collection in tissue): 2 people, 11.76%
Depression: 2 people, 11.76%
Diabetes: 2 people, 11.76%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 11.76%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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