Phenergan and Carpine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Carpine (pilocarpine hydrochloride). Common drug interactions include abdominal pain upper among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Phenergan and Carpine. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Carpine?

Carpine has active ingredients of pilocarpine hydrochloride. eHealthMe is studying from 5,561 Carpine users. Check the latest studies of Carpine.

On Jul, 28, 2026

16 people who take Phenergan and Carpine together, and have interactions are studied.

Phenergan and Carpine drug interactions.

What are the common drug interactions of Phenergan and Carpine, by gender? *:

female:

Abdominal pain upper
Constipation
Abdominal distension
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Depression
Drug hypersensitivity
Abdominal discomfort
Abdominal pain
Alopecia (absence of hair from areas of the body)

male:

Diarrhoea
Alanine aminotransferase increased
Blood magnesium decreased
Blood pressure increased
Bradycardia (abnormally slow heart action)
Cardiac failure congestive
Cough
Death
Dental caries
Dizziness

What are the common drug interactions of Phenergan and Carpine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Constipation
Drug ineffective
Fluid retention (an abnormal accumulation of fluid in the blood)
Peripheral swelling
Pulmonary oedema (fluid accumulation in the lungs)

50-59:

Abdominal pain upper
Anxiety
Back pain
Bladder obstruction
Blood pressure increased
Bradycardia (abnormally slow heart action)
Cardiac failure congestive
Cough
Depression
Diarrhoea

60+:

Diarrhoea
Abdominal distension
Alopecia (absence of hair from areas of the body)
Androgenetic alopecia (common form of hair loss)
Angiopathy (generic term for a disease of the blood vessels)
Aspartate aminotransferase increased
Blood albumin decreased
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood magnesium decreased

What are the existing conditions these people have? *

Dry Mouth: 3 people, 18.75%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 18.75%
Neuropathy Peripheral (surface nerve damage): 3 people, 18.75%
Immune System Disorder: 2 people, 12.50%
Muscle Spasms (muscle contraction): 2 people, 12.50%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 12.50%
Back Pain: 2 people, 12.50%
Cardiac Disorder: 2 people, 12.50%
Dry Eyes (lack of adequate tears): 2 people, 12.50%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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