Phenergan and Cefzil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Cefzil (cefprozil). Common drug interactions include impaired gastric emptying among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Phenergan and Cefzil. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Cefzil?

Cefzil has active ingredients of cefprozil. It is often used in sinusitis. eHealthMe is studying from 1,106 Cefzil users. Check the latest studies of Cefzil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

31 people who take Phenergan and Cefzil together, and have interactions are studied.

What are the common drug interactions of Phenergan and Cefzil, by gender? *:

female:

Impaired gastric emptying
Irritable bowel syndrome
Loss of employment
Lung consolidation (a condition whereby the lung tissues solidify because of the accumulation of solid and liquid material in the air spaces)
Lung disorder (lung disease)
Maternal exposure during pregnancy (use of substance during pregnancy)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Multiple fractures
Multiple injuries
Nasopharyngitis (inflammation of the nasopharynx)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Renal failure (kidney dysfunction)
Renal infarct (kidney damage due to lack of blood supply)
Renal injury (kidney injury)
Diarrhoea
Gastric disorder (disease of stomach)
Malaise (a feeling of general discomfort or uneasiness)
Coarctation of the aorta (narrowing of the part of aorta)
Depression

What are the common drug interactions of Phenergan and Cefzil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anxiety
Dyspnoea (difficult or laboured respiration)
Emotional distress
General physical health deterioration (weak health status)
Injury
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)

20-29:

Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Oropharyngeal pain
Pulmonary embolism (blockage of the main artery of the lung)
Tonsillitis (inflammation of tonsil)

30-39:

n/a

40-49:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Multiple injuries
Muscular weakness (muscle weakness)
Nasopharyngitis (inflammation of the nasopharynx)
Oedema genital (fluid collection in tissue of genitals)
Oedema peripheral (superficial swelling)
Overweight
Oxygen saturation decreased
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Diarrhoea
Gastric disorder (disease of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Impaired gastric emptying
Malaise (a feeling of general discomfort or uneasiness)
Renal failure (kidney dysfunction)

60+:

Chest pain
Fall
Neck pain
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Peripheral vascular disorder
Arthropathy
Bone disorder
Anxiety
Aortic aneurysm rupture (enlarged aortic artery rapture caused by a weakening of the artery wall)

What are the existing conditions these people have? *

Stress And Anxiety: 15 people, 48.39%
Depression: 14 people, 45.16%
Pain: 12 people, 38.71%
High Blood Cholesterol: 11 people, 35.48%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 35.48%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 25.81%
Chest Pain: 8 people, 25.81%
Osteoporosis (bones weak and more likely to break): 8 people, 25.81%
Bladder Spasm: 7 people, 22.58%
Cardiac Disorder: 7 people, 22.58%

* Approximation only. Some reports may have incomplete information.

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