Phenergan and Diprivan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Diprivan (propofol). Common drug interactions include oedema peripheral among females and thrombocytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Phenergan and Diprivan. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Diprivan?

Diprivan has active ingredients of propofol. eHealthMe is studying from 6,496 Diprivan users. Check the latest studies of Diprivan.

On Aug, 11, 2026

52 people who take Phenergan and Diprivan together, and have interactions are studied.

Phenergan and Diprivan drug interactions.

What are the common drug interactions of Phenergan and Diprivan, by gender? *:

female:

Oedema peripheral (superficial swelling)
Pain
Pain in extremity
Renal failure (kidney dysfunction)
Abdominal infection
Alanine aminotransferase increased
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bradyarrhythmia (heart slowness)
Bradycardia (abnormally slow heart action)

male:

Thrombocytopenia (decrease of platelets in blood)
Sepsis (a severe blood infection that can lead to organ failure and death)
Renal failure (kidney dysfunction)
Abdominal pain upper
Bacteraemia (presence of bacteria in the blood)
Blood creatinine increased
Drug effect decreased
Hypotension (abnormally low blood pressure)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Phenergan and Diprivan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alanine aminotransferase increased
Aspartate aminotransferase increased

10-19:

Abdominal pain
Alanine aminotransferase increased
Aspartate aminotransferase increased
Gamma-glutamyltransferase increased
Headache (pain in head)
Hepatic trauma (liver injury)
Hepatitis (inflammation of the liver)
Hypersensitivity

20-29:

Abdominal distension
Aggression
Back pain
Blood cholesterol increased
Bradyarrhythmia (heart slowness)
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac flutter (abnormal heart rhythm)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chest tightness

30-39:

Breast enlargement
Menstruation irregular
Pelvic pain
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Abdominal pain
Cavernous sinus thrombosis (formation of a blood clot in brain)
Confusional state
Headache (pain in head)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Right ventricular failure (right half of the heart fails to work)

40-49:

Abdominal distension
Abdominal pain
Device dislocation
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Breast cancer in situ
Breast mass
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation
Carotid bruit (sound heard over the carotid artery area during auscultation)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colonic polyp (extra part of colon tissue grow in intestine)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dizziness

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Unresponsive to stimuli
Blood creatinine increased
Cardiac failure
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
General physical health deterioration (weak health status)
Pyrexia (fever)
Acute respiratory distress syndrome
Cytokine storm (over-protective immune response that can actually be fatal)

What are the existing conditions these people have? *

Pain: 9 people, 17.31%
Depression: 6 people, 11.54%
Constipation: 4 people, 7.69%
Muscle Spasms (muscle contraction): 3 people, 5.77%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 5.77%
Migraine Without Aura (headache without neurological problems): 3 people, 5.77%
Hypotension (abnormally low blood pressure): 3 people, 5.77%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 5.77%
High Blood Pressure: 3 people, 5.77%
Heart Attack: 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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