Phenergan and Esgic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Esgic (acetaminophen; butalbital; caffeine). Common drug interactions include depression among females and dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Phenergan and Esgic. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Esgic?

Esgic has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 882 Esgic users. Check the latest studies of Esgic.

On Jul, 08, 2026

65 people who take Phenergan and Esgic together, and have interactions are studied.

What are the common drug interactions of Phenergan and Esgic, by gender? *:

female:

Depression
Fall
Anxiety
Drug ineffective
Pruritus (severe itching of the skin)
Weight decreased
Abdominal pain
Diarrhoea
Fatigue (feeling of tiredness)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)

male:

Dependence
Back disorder
Dependent personality disorder
Loss of consciousness
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Personality disorder
Weight increased

What are the common drug interactions of Phenergan and Esgic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pain
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal pain
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Anxiety
Cholecystitis chronic (long lasting infection of gallbladder)
Dependence
Emotional distress
Gallbladder disorder
General physical health deterioration (weak health status)

30-39:

Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Herpes simplex (herpes simplex is a common viral infection)
Hyperglycaemia (high blood sugar)
Irritability
Joint swelling
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Pancreatitis chronic (chronic inflammation of pancreas)
Pancreatitis relapsing

40-49:

Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Depression
Injection site erythema (redness at injection site)
Pancreatitis (inflammation of pancreas)
Abdominal adhesions (inflammation of abdomen)
Abdominal pain
Abdominal pain upper
Alanine aminotransferase increased
Anger

50-59:

Drug ineffective
Bacterial sepsis
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Dehydration (dryness resulting from the removal of water)
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
Fall
Neck injury
Pain
Pancreatic cyst
Vertigo

60+:

Blood glucose decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Weight increased
Fall
Joint injury
Multiple allergies (allergy to multiple agents)
Poor venous access
Sinus disorder (disease of sinus)
Sinusitis (inflammation of sinus)
Cough

What are the existing conditions these people have? *

Headache (pain in head): 13 people, 20.00%
Depression: 11 people, 16.92%
Pain: 10 people, 15.38%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 12.31%
Muscle Spasms (muscle contraction): 7 people, 10.77%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 10.77%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 9.23%
Hypersensitivity: 6 people, 9.23%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 9.23%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 9.23%

* Approximation only. Some reports may have incomplete information.

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