Phenergan and Folate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Folate (folic acid). Common drug interactions include clostridium difficile colitis among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Phenergan and Folate. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

On Jul, 08, 2026

53 people who take Phenergan and Folate together, and have interactions are studied.

What are the common drug interactions of Phenergan and Folate, by gender? *:

female:

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Foot fracture
Night sweats (sweating in night)
Urinary tract infection
Depression
Neck pain
Renal impairment (severely reduced kidney function)
Abscess oral (abscess in the mouth)
Acquired oesophageal web (structural abnormalities in the oesophagus)
Antinuclear antibody positive

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Abscess oral (abscess in the mouth)
Acquired oesophageal web (structural abnormalities in the oesophagus)
Actinomycosis (infection that causes sores, or abscesses)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Antinuclear antibody positive
Arthralgia (joint pain)
Arthropathy

What are the common drug interactions of Phenergan and Folate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pain
Abdominal discomfort
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Back pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Emotional distress
Fall

20-29:

Chest pain
Electrocardiogram qt prolonged
Injection site swelling
Syncope (loss of consciousness with an inability to maintain postural tone)

30-39:

Anaemia (lack of blood)
Anogenital warts
Blood sodium decreased
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Electrolyte imbalance
Gastroenteritis (inflammation of stomach and intestine)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyperkalaemia (damage to or disease of the kidney)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)

40-49:

Abdominal pain upper
Fungal infection
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Acquired oesophageal web (structural abnormalities in the oesophagus)
Antinuclear antibody positive
Arthralgia (joint pain)
Asthma
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone marrow failure
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Dental discomfort
Dysphagia (a condition in which swallowing is difficult or painful)
Fat tissue increased

60+:

Anxiety
Fall
Diarrhoea
Duodenal ulcer haemorrhage (bleeding duodenal ulcer)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Joint range of motion decreased (disease of joint movement)
Large intestine perforation (hole in large intestine)
Myalgia (muscle pain)
Pleural effusion (water on the lungs)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 26.42%
Stress And Anxiety: 8 people, 15.09%
Pain: 6 people, 11.32%
Diarrhea: 6 people, 11.32%
High Blood Pressure: 5 people, 9.43%
Hiv Infection: 5 people, 9.43%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 9.43%
Hypersensitivity: 4 people, 7.55%
Constipation: 4 people, 7.55%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 7.55%

* Approximation only. Some reports may have incomplete information.

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