Phenergan and Kadian drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Kadian (morphine sulfate). Common drug interactions include neuritis among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Phenergan and Kadian. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Kadian?

Kadian has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 23,045 Kadian users. Check the latest studies of Kadian.

On Jul, 11, 2026

44 people who take Phenergan and Kadian together, and have interactions are studied.

What are the common drug interactions of Phenergan and Kadian, by gender? *:

female:

Neuritis (inflammation of nerve)
Panic attack
Patellofemoral pain syndrome (pain in the front of the knee)
Polydipsia (excessive thirst)
Polyuria (production of too much dilute urine)
Psychomotor skills impaired
Temperature intolerance (inability to go in temperature)
Thyroid neoplasm (tumour of thyroid)
Abdominal pain
Cellulitis (infection under the skin)

male:

Pneumonia
Pyrexia (fever)
Back injury
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Dilatation ventricular
Ejection fraction decreased (systolic heart failure)
Frequent bowel movements
Haemoglobin decreased
Muscle oedema (accumulation of free water in muscle)
Osteoporosis (bones weak and more likely to break)

What are the common drug interactions of Phenergan and Kadian, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Headache (pain in head)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Arthralgia (joint pain)
Balance disorder
Bladder spasm
Breast abscess
Breast cellulitis (spreading, acute inflammation of beast skin)
Breast tenderness
Chest pain

40-49:

Thoracic vertebral fracture
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiomegaly (increased size of heart than normal)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Joint effusion (presence of extra fluid in joint covering)
Pleural effusion (water on the lungs)
Pulmonary embolism (blockage of the main artery of the lung)

50-59:

Cellulitis (infection under the skin)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
White blood cell count decreased
Fatigue (feeling of tiredness)
Impaired gastric emptying
Injection site bruising
Myositis (inflammation of the muscles)
Weight increased
Appetite disorder (abnormal eating habits)
Constipation

60+:

Abdominal distension
Abdominal pain
Lack of spontaneous speech
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Muscle spasms (muscle contraction)
Muscle twitching
Pneumonia
Pyrexia (fever)
Renal failure (kidney dysfunction)
Suicidal ideation

What are the existing conditions these people have? *

Insomnia (sleeplessness): 11 people, 25.00%
Anaemia (lack of blood): 7 people, 15.91%
Multiple Myeloma (cancer of the plasma cells): 5 people, 11.36%
Iron Overload: 5 people, 11.36%
Back Pain: 5 people, 11.36%
Depression: 4 people, 9.09%
Headache (pain in head): 3 people, 6.82%
Growth Hormone Deficiency: 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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