Phenergan and Ocrevus drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Ocrevus (ocrelizumab). Common drug interactions include alopecia among females and dysphagia among males.
The phase IV clinical study analyzes what interactions people have when they take Phenergan and Ocrevus. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.
What is Phenergan?
Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.
What is Ocrevus?
Ocrevus has active ingredients of ocrelizumab. eHealthMe is studying from 56,583 Ocrevus users. Check the latest studies of Ocrevus.
72 people who take Phenergan and Ocrevus together, and have interactions are studied.

What are the common drug interactions of Phenergan and Ocrevus, by gender? *:
female:
- Alopecia (absence of hair from areas of the body)
- Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
- Blood cholesterol increased
- Foot fracture
- Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
- Pityriasis rosea (itchy rash develops over the trunk and extremities)
- Pruritus (severe itching of the skin)
- Seizure (abnormal excessive or synchronous neuronal activity in the brain)
- Suicide attempt
- Blood potassium decreased
male:
- Dysphagia (a condition in which swallowing is difficult or painful)
- Oedema (fluid collection in tissue)
- Cartilage injury
- Depression
- Exostosis (formation of new bone on the surface of a bone)
- Facial pain
- Fall
- Headache (pain in head)
- Hypotension (abnormally low blood pressure)
- Lyme disease (a bacterial infection that is spread to humans by infected ticks)
What are the common drug interactions of Phenergan and Ocrevus, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Blindness transient (sudden loss of vision)
- Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Visual field defect
- Contusion (a type of hematoma of tissue in which capillaries)
- Gait disturbance
- Mobility decreased (ability to move is reduced)
- Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
- Skin burning sensation
- Swelling
40-49:
- Fatigue (feeling of tiredness)
- Back pain
- Asthenia (weakness)
- Hypoaesthesia (reduced sense of touch or sensation)
- Blood phosphorus decreased
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Alopecia (absence of hair from areas of the body)
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
- Drug hypersensitivity
- Blood parathyroid hormone increased
50-59:
- Chest pain
- Foot fracture
- Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
- Memory impairment
- Pityriasis rosea (itchy rash develops over the trunk and extremities)
- Suicide attempt
- Infection
- Visual impairment
- Abdominal pain
- Dental caries
60+:
- Headache (pain in head)
- Dysphagia (a condition in which swallowing is difficult or painful)
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Pain
- Tremor (trembling or shaking movements in one or more parts of your body)
- Ageusia (loss of taste functions of the tongue)
- Bone pain
- Cartilage injury
- Chest pain
- Cough
What are the existing conditions these people have? *
- Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 23 people, 31.94%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 20 people, 27.78%
- Pain: 17 people, 23.61%
- Muscle Spasms (muscle contraction): 14 people, 19.44%
- Depression: 13 people, 18.06%
- Migraine (headache): 10 people, 13.89%
- Stress And Anxiety: 9 people, 12.50%
- Fatigue (feeling of tiredness): 9 people, 12.50%
- Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 8 people, 11.11%
- Nausea And Vomiting: 6 people, 8.33%
* Approximation only. Some reports may have incomplete information.
Do you take Phenergan and Ocrevus?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Phenergan and Ocrevus:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Phenergan:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Ocrevus:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Phenergan and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Ocrevus and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
- Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on promethazine hydrochloride and ocrelizumab (the active ingredients of Phenergan and Ocrevus, respectively), and Phenergan and Ocrevus (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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