Phenergan and Proamatine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Proamatine (midodrine hydrochloride). Common drug interactions include ocular icterus among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Phenergan and Proamatine. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Proamatine?

Proamatine has active ingredients of midodrine hydrochloride. It is often used in hypotension. eHealthMe is studying from 968 Proamatine users. Check the latest studies of Proamatine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

28 people who take Phenergan and Proamatine together, and have interactions are studied.

Phenergan and Proamatine drug interactions.

What are the common drug interactions of Phenergan and Proamatine, by gender? *:

female:

Ocular icterus (presence of jaundice seen in the sclera of the eye)
Oedema peripheral (superficial swelling)
Pain of skin
Pneumonia
Postmenopausal haemorrhage (post-menopausal bleeding)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Skin plaque (red, scaly patches to appear on the skin)
Skin tightness

male:

Cardiac failure congestive
Pneumonia
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hepatic failure (liver failure)
Liver disorder (liver diseases)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Phenergan and Proamatine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Rectal haemorrhage (bleeding from anus)
Suicidal ideation
Adrenal disorder
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Blindness

30-39:

n/a

40-49:

Arthralgia (joint pain)
Asthenia (weakness)
Deformity (disfigurement)
Erythema (redness of the skin)
Exfoliative rash (scaly red generalized skin rash)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Gait disturbance
General physical health deterioration (weak health status)
Joint contracture (a permanent shortening of a muscle or joint)
Joint range of motion decreased (disease of joint movement)

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Arrhythmia (irregular heartbeat)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Cardiac failure congestive
Cardiac output decreased
Cardiogenic shock (inadequate circulation of blood)
Cerebellar ischaemia (lack of blood supply to cerebeller)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematoma (collection of blood outside the blood vessels)

60+:

Diplegia (paralysis of corresponding parts on both sides of the body)
Haemorrhage (bleeding)
Oesophageal candidiasis (fungal infection of oesophagus)
Pharyngeal disorder
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Aplasia pure red cell (type of anaemia affecting the precursors to red blood cells but not to white blood cells)
Blood erythropoietin increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Decreased appetite

What are the existing conditions these people have? *

Pain: 4 people, 14.29%
Stress And Anxiety: 3 people, 10.71%
Nausea And Vomiting: 3 people, 10.71%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 7.14%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 7.14%
Peripheral Arterial Occlusive Disease (reproducible ischemic muscle pain): 2 people, 7.14%
Pain In Extremity: 2 people, 7.14%
Neuropathy Peripheral (surface nerve damage): 2 people, 7.14%
Migraine (headache): 2 people, 7.14%
High Blood Pressure: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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