Phenergan and Simponi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Simponi (golimumab). Common drug interactions include drug hypersensitivity among females and acute respiratory distress syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Phenergan and Simponi. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Simponi?

Simponi has active ingredients of golimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 86,328 Simponi users. Check the latest studies of Simponi.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

77 people who take Phenergan and Simponi together, and have interactions are studied.

Phenergan and Simponi drug interactions.

What are the common drug interactions of Phenergan and Simponi, by gender? *:

female:

Drug hypersensitivity
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Pruritus (severe itching of the skin)
Abdominal pain
Appetite disorder (abnormal eating habits)
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Chills (felling of cold)
Constipation

male:

Acute respiratory distress syndrome
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea infectious (bacteria, viruses, and other germs can cause diarrhoea)
Hodgkin's disease (cancer originating from white blood cells)
Interstitial lung disease
Gastrointestinal inflammation (inflammation of stomach and intestine)
Pneumonia
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Cardiac failure
Pain in extremity

What are the common drug interactions of Phenergan and Simponi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Malaise (a feeling of general discomfort or uneasiness)

30-39:

Pain in extremity

40-49:

Meningitis viral (viral inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Gastrointestinal inflammation (inflammation of stomach and intestine)
Hypersensitivity
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Migraine (headache)
Pneumonia
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

50-59:

Acute respiratory distress syndrome
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea infectious (bacteria, viruses, and other germs can cause diarrhoea)
Hodgkin's disease (cancer originating from white blood cells)
Interstitial lung disease
Mass
Nasopharyngitis (inflammation of the nasopharynx)
Otitis media (inflammation of the middle ear)
Pyrexia (fever)
Sinusitis (inflammation of sinus)

60+:

Drug hypersensitivity
Abdominal pain
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphoria (generalized dissatisfaction with life)
Ear pain
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Gait disturbance
Haemorrhagic diathesis (bleeding tendency)

What are the existing conditions these people have? *

Dizziness: 47 people, 61.04%
Pain: 16 people, 20.78%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 6 people, 7.79%
High Blood Pressure: 6 people, 7.79%
Sleep Disorder: 4 people, 5.19%
High Blood Cholesterol: 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

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