Phenergan and Zestoretic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenergan (promethazine hydrochloride) and Zestoretic (hydrochlorothiazide; lisinopril). Common drug interactions include diabetes mellitus among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Phenergan and Zestoretic. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

On Jul, 12, 2026

32 people who take Phenergan and Zestoretic together, and have interactions are studied.

Phenergan and Zestoretic drug interactions.

What are the common drug interactions of Phenergan and Zestoretic, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypotension (abnormally low blood pressure)
Interstitial lung disease
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Urinary tract infection

male:

Pain
Dizziness
Dehydration (dryness resulting from the removal of water)
Emotional distress
Tooth fracture
Weight decreased
Abdominal pain
Arthralgia (joint pain)
Back pain
Blood creatinine increased

What are the common drug interactions of Phenergan and Zestoretic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fall
Humerus fracture (injury to the upper arm bone)
Hyperglycaemia (high blood sugar)
Multiple fractures
Osteoporosis (bones weak and more likely to break)
Pregnancy
Upper limb fracture

30-39:

n/a

40-49:

Anxiety
Chronic kidney disease
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dizziness
Emotional distress
Febrile neutropenia (fever with reduced white blood cells)
Tooth fracture
Bone density decreased
Dehydration (dryness resulting from the removal of water)

50-59:

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Multi-organ failure (multisystem organ failure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Pancreatitis (inflammation of pancreas)
Plasma cell myeloma (cancer that begins in plasma cells)
Anaemia (lack of blood)
Hypotension (abnormally low blood pressure)
Interstitial lung disease
Renal failure (kidney dysfunction)

60+:

Neoplasm malignant (cancer tumour)
Decreased appetite
Blood glucose increased
Cardiac failure congestive
Chronic kidney disease
Constipation
Dizziness
Drug ineffective
Ear pain
Epistaxis (bleed from the nose)

What are the existing conditions these people have? *

Pain: 8 people, 25.00%
Stress And Anxiety: 7 people, 21.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 18.75%
Depression: 5 people, 15.62%
Nausea And Vomiting: 5 people, 15.62%
Hiv Infection: 4 people, 12.50%
Bleeding Disorders: 4 people, 12.50%
Neuralgia (pain in one or more nerves): 4 people, 12.50%
Type 2 Diabetes: 3 people, 9.38%
Blood Glucose Abnormal: 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

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