Phentermine and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phentermine (phentermine hydrochloride) and Nucynta (tapentadol hydrochloride). Common drug interactions include sinusitis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Phentermine and Nucynta. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Phentermine?

Phentermine has active ingredients of phentermine hydrochloride. It is often used in weight loss. eHealthMe is studying from 19,870 Phentermine users. Check the latest studies of Phentermine.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Jul, 14, 2026

28 people who take Phentermine and Nucynta together, and have interactions are studied.

Phentermine and Nucynta drug interactions.

What are the common drug interactions of Phentermine and Nucynta, by gender? *:

female:

Sinusitis (inflammation of sinus)
Chronic kidney disease
Headache (pain in head)
Unresponsive to stimuli
Acute myocardial infarction (acute heart attack)
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Asthma
Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Blood potassium decreased

male:

Chronic kidney disease
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)
Herpes zoster
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Insomnia (sleeplessness)
Vomiting

What are the common drug interactions of Phentermine and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Overdose
Unresponsive to stimuli

20-29:

n/a

30-39:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Hallucination (an experience involving the perception of something not present)
Suicide attempt
Unresponsive to stimuli
Vomiting

40-49:

Cardiac failure congestive
Chest pain
Chronic kidney disease
Congestive cardiomyopathy (weakening of heart muscle)
Fall
Headache (pain in head)
Hunger
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

Chronic kidney disease
Fatigue (feeling of tiredness)
Herpes zoster
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Papillary thyroid cancer
Thyroid mass

60+:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 35.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 21.43%
Infection: 5 people, 17.86%
High Blood Cholesterol: 5 people, 17.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 17.86%
Rickets (softening of bones): 3 people, 10.71%
Pulmonary Congestion (congestion in the lungs): 3 people, 10.71%
Hypertensive Crisis: 3 people, 10.71%
High Blood Pressure: 3 people, 10.71%
Constipation: 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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