Phentermine and Requip drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phentermine (phentermine hydrochloride) and Requip (ropinirole hydrochloride). Common drug interactions include cerebrovascular accident among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Phentermine and Requip. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Phentermine?

Phentermine has active ingredients of phentermine hydrochloride. It is often used in weight loss. eHealthMe is studying from 19,870 Phentermine users. Check the latest studies of Phentermine.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

33 people who take Phentermine and Requip together, and have interactions are studied.

Phentermine and Requip drug interactions.

What are the common drug interactions of Phentermine and Requip, by gender? *:

female:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Fall
Fatigue (feeling of tiredness)
Haemolytic uraemic syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more)
Hypertension (high blood pressure)
Nephrolithiasis (calculi in the kidneys)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress

male:

Dizziness
Fatigue (feeling of tiredness)
Weight increased
Bladder cancer
Fungal infection
Rectal cancer (cancer of rectum)

What are the common drug interactions of Phentermine and Requip, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Coma (state of unconsciousness lasting more than six hours)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Overdose
Respiratory failure (inadequate gas exchange by the respiratory system)
Suicide attempt
Transaminases increased

40-49:

Chronic kidney disease
Alopecia (absence of hair from areas of the body)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Fall
Hand fracture
Psychological trauma
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

50-59:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Chest pain
Dyspnoea (difficult or laboured respiration)
Aortic calcification (aortic calcification sign of heart valve disease)
Crying
Depressed mood
Depression
Emotional disorder
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)

60+:

Dizziness
Fatigue (feeling of tiredness)
Hepatic steatosis (fatty liver disease)
Metastases to ovary (cancer spreads to ovary)
Metastases to peritoneum (cancer spreads to peritoneum)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Pancreatitis chronic (chronic inflammation of pancreas)
Pulmonary mass
Skin cancer
Abscess jaw (tooth abscess or root abscess)

What are the existing conditions these people have? *

Pain: 15 people, 45.45%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 42.42%
High Blood Cholesterol: 11 people, 33.33%
Depression: 11 people, 33.33%
High Blood Pressure: 9 people, 27.27%
Parkinson's Disease: 7 people, 21.21%
Hypokalemia (low potassium): 7 people, 21.21%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 18.18%
Insomnia (sleeplessness): 6 people, 18.18%
Neuropathy Peripheral (surface nerve damage): 6 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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