Phentermine and Zestoretic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phentermine (phentermine hydrochloride) and Zestoretic (hydrochlorothiazide; lisinopril). Common drug interactions include chronic kidney disease among females.

The phase IV clinical study analyzes what interactions people have when they take Phentermine and Zestoretic. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Phentermine?

Phentermine has active ingredients of phentermine hydrochloride. It is often used in weight loss. eHealthMe is studying from 19,870 Phentermine users. Check the latest studies of Phentermine.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

On Aug, 04, 2026

12 people who take Phentermine and Zestoretic together, and have interactions are studied.

Phentermine and Zestoretic drug interactions.

What are the common drug interactions of Phentermine and Zestoretic, by gender? *:

female:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthralgia (joint pain)
Asthenia (weakness)
Cardiac failure
Chest pain
Constipation
Drug effect decreased
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

male:

n/a

What are the common drug interactions of Phentermine and Zestoretic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthenia (weakness)
Cardiovascular disorder (heart diseases)
Constipation
Gastroenteritis (inflammation of stomach and intestine)
Oedema peripheral (superficial swelling)
Palpitations (feelings or sensations that your heart is pounding or racing)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Facial palsy (paralysis of face nerve)
Abasia (inability to walk)
Arthralgia (joint pain)
Cardiovascular disorder (heart diseases)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hypoaesthesia (reduced sense of touch or sensation)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

50-59:

Cardiovascular disorder (heart diseases)
Chest pain
Dyspnoea (difficult or laboured respiration)
Pain
Angina pectoris (chest pain due to ischemia of the heart muscle)
Cardiac failure

60+:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Kidney fibrosis (excess fibrous connective tissue in kidney)
Renal failure (kidney dysfunction)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)
Drug effect decreased
Pain in extremity

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 25.00%
Cardiac Disorder: 3 people, 25.00%
Pain: 2 people, 16.67%
Hypersensitivity: 2 people, 16.67%
Asthma: 2 people, 16.67%
Sleep Disorder: 1 person, 8.33%
Rickets (softening of bones): 1 person, 8.33%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 8.33%
Neuralgia (pain in one or more nerves): 1 person, 8.33%
Nausea (feeling of having an urge to vomit): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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