Phenytek and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenytek (phenytoin sodium) and Keppra (levetiracetam). Common drug interactions include cardiac failure among females and cerebellar atrophy among males.

The phase IV clinical study analyzes what interactions people have when they take Phenytek and Keppra. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Phenytek?

Phenytek has active ingredients of phenytoin sodium. It is often used in seizures. eHealthMe is studying from 167 Phenytek users. Check the latest studies of Phenytek.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

On Jul, 17, 2026

23 people who take Phenytek and Keppra together, and have interactions are studied.

What are the common drug interactions of Phenytek and Keppra, by gender? *:

female:

Cardiac failure
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
General physical condition
Malaise (a feeling of general discomfort or uneasiness)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Abdominal pain upper
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anticonvulsant drug level below therapeutic
Anxiety
Burning sensation

male:

Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Gingival hypertrophy (overgrowth of gums)
Neuropathy peripheral (surface nerve damage)
Speech disorder
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal pain
Constipation
Dysuria (painful or difficult urination)
Faeces discoloured
Haematochezia (passage of stools containing blood)

What are the common drug interactions of Phenytek and Keppra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Gingival hypertrophy (overgrowth of gums)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ataxia (loss of full control of bodily movements)
Balance disorder
Disturbance in attention
Gait disturbance
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Muscular weakness (muscle weakness)

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Drug hypersensitivity
Emotional distress
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Injury
Pain
Skin fibrosis (fibrous tissue formation on skin)

50-59:

Faeces discoloured
Haematochezia (passage of stools containing blood)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Pancreatitis (inflammation of pancreas)
Pleural effusion (water on the lungs)
Abdominal pain
Constipation
Dysuria (painful or difficult urination)

60+:

Cardiac failure
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
General physical condition
Malaise (a feeling of general discomfort or uneasiness)
Asthenia (weakness)
Drug resistance (reduction in effectiveness of a drug)
Fall

What are the existing conditions these people have? *

Hyperkalemia (damage to or disease of the kidney): 6 people, 26.09%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 17.39%
Pain: 4 people, 17.39%
Nausea And Vomiting: 4 people, 17.39%
Nausea (feeling of having an urge to vomit): 4 people, 17.39%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 17.39%
Muscle Spasms (muscle contraction): 3 people, 13.04%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 13.04%
High Blood Pressure: 3 people, 13.04%
Multiple Allergies (allergy to multiple agents): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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