Phenytoin and Sucralfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenytoin (phenytoin) and Sucralfate (sucralfate). Common drug interactions include musculoskeletal pain among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Phenytoin and Sucralfate. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

What is Sucralfate?

Sucralfate has active ingredients of sucralfate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 17,548 Sucralfate users. Check the latest studies of Sucralfate.

On Jul, 15, 2026

62 people who take Phenytoin and Sucralfate together, and have interactions are studied.

Phenytoin and Sucralfate drug interactions.

What are the common drug interactions of Phenytoin and Sucralfate, by gender? *:

female:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Oedema (fluid collection in tissue)
Pain
Pain in extremity
Skin fibrosis (fibrous tissue formation on skin)
Skin hyperpigmentation (disorders affect the colour of your skin)
Thrombocytopenia (decrease of platelets in blood)
Weakness

male:

Pneumonia
Febrile neutropenia (fever with reduced white blood cells)
Aspartate aminotransferase increased
Blood lactate dehydrogenase increased
Blood urea increased
Gamma-glutamyltransferase increased
Leukocytosis (increased white blood cells)
Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood)
Rash
Arthralgia (joint pain)

What are the common drug interactions of Phenytoin and Sucralfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug level decreased
Nausea (feeling of having an urge to vomit)
Vomiting
Retching (strong involuntary effort to vomit)
Cellulitis orbital (acute spread of infection into the eye socket)
Encephalitis (inflammation of the brain)
Lacunar infarction (a type of stroke)
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Osteonecrosis (death of bone)
Sinusitis fungal (fungal infection of sinus)

20-29:

Fall
Hypoaesthesia (reduced sense of touch or sensation)
Thrombocytopenia (decrease of platelets in blood)
Abnormal behaviour
Agitation (state of anxiety or nervous excitement)
Arthralgia (joint pain)
Blood osmolarity increased
Blood pressure increased
Brief psychotic disorder, without marked stressor(s)
Chest pain

30-39:

Eosinophil count increased
Eosinophil percentage increased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haematoma (collection of blood outside the blood vessels)
Haemoglobin decreased
Ingrowing nail
Myoclonic jerks (involuntary twitching of a muscle or group of muscles)
Oxygen saturation decreased
Pleurisy (inflammation of the pleurae, which causes pain when breathing)

40-49:

Arrhythmia (irregular heartbeat)
Bezoar (mass found trapped in the gastrointestinal system)
Chronic kidney disease
Coma (state of unconsciousness lasting more than six hours)
Food interaction
Oesophageal obstruction (blockage of oesophagus)
Renal failure (kidney dysfunction)
Urine discolouration

50-59:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Decreased activity
Depression
Emotional distress
Fatigue (feeling of tiredness)
Fear
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

60+:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Mucosal erosion (peeling off of mucous membrane)
Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood)
Pyrexia (fever)
Rash
Febrile neutropenia (fever with reduced white blood cells)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Constipation
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 8 people, 12.90%
Pain: 5 people, 8.06%
Infection: 5 people, 8.06%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 8.06%
Nuclear Magnetic Resonance Imaging Brain: 4 people, 6.45%
Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina): 4 people, 6.45%
Hypersensitivity: 4 people, 6.45%
Cough: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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