Phenytoin and Temodar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenytoin (phenytoin) and Temodar (temozolomide). Common drug interactions include thrombocytopenia among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Phenytoin and Temodar. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

What is Temodar?

Temodar has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 6,683 Temodar users. Check the latest studies of Temodar.

On Jul, 08, 2026

26 people who take Phenytoin and Temodar together, and have interactions are studied.

Phenytoin and Temodar drug interactions.

What are the common drug interactions of Phenytoin and Temodar, by gender? *:

female:

Thrombocytopenia (decrease of platelets in blood)
Alanine aminotransferase decreased
Aspartate aminotransferase decreased
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Haemoglobin decreased
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

male:

Nausea (feeling of having an urge to vomit)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Fatigue (feeling of tiredness)
Oedema (fluid collection in tissue)
Pruritus (severe itching of the skin)
Sedation
Insomnia (sleeplessness)
Vomiting
Anticonvulsant drug level increased
Apraxia (disorder that affects a person's ability to organize the movements of the muscles used in speech)

What are the common drug interactions of Phenytoin and Temodar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Serum sickness (hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum)
Dysphagia (a condition in which swallowing is difficult or painful)
Face oedema (swelling of face)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Sedation

40-49:

n/a

50-59:

Blood potassium decreased
Blood pressure inadequately controlled
Contusion (a type of hematoma of tissue in which capillaries)
Epistaxis (bleed from the nose)
Fall
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haematemesis (vomiting of blood)
Haemorrhage intracranial (bleeding within the skull)
Hemiparesis (weakness on one side of the body)
Hydrocephalus (water on the brain)

60+:

Thrombocytopenia (decrease of platelets in blood)
Disease progression
Anaemia (lack of blood)
Aphasia (damage to the parts of the brain that control language)
Apraxia (disorder that affects a person's ability to organize the movements of the muscles used in speech)
Asthenia (weakness)
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain

What are the existing conditions these people have? *

Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 4 people, 15.38%
Brain Neoplasm (tumour of brain): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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