Phenytoin and Temozolomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phenytoin (phenytoin) and Temozolomide (temozolomide). Common drug interactions include gingival bleeding among females and ophthalmoplegia among males.

The phase IV clinical study analyzes what interactions people have when they take Phenytoin and Temozolomide. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

What is Temozolomide?

Temozolomide has active ingredients of temozolomide. It is often used in glioblastoma multiforme. eHealthMe is studying from 16,644 Temozolomide users. Check the latest studies of Temozolomide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

86 people who take Phenytoin and Temozolomide together, and have interactions are studied.

Phenytoin and Temozolomide drug interactions.

What are the common drug interactions of Phenytoin and Temozolomide, by gender? *:

female:

Gingival bleeding (bleeding gums)
Hyperglycaemia (high blood sugar)
Lymphocyte count decreased
Monocyte count decreased
Dizziness
Drug eruption (adverse drug reaction of the skin)
Escherichia infection (bacterial infection by escherichia coli)
Fatigue (feeling of tiredness)
Asthenia (weakness)
Blood albumin decreased

male:

Ophthalmoplegia (a paralysis or weakness of one or more of the muscles that control eye movement)
Diplopia (double vision)
Pulmonary embolism (blockage of the main artery of the lung)
Wound infection
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Abdominal pain
Confusional state
Drug hypersensitivity
Headache (pain in head)
Neoplasm progression (growth of tumour)

What are the common drug interactions of Phenytoin and Temozolomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells)
Death
Disease recurrence

30-39:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Bone marrow failure
Gingival bleeding (bleeding gums)
Sepsis (a severe blood infection that can lead to organ failure and death)
General physical health deterioration (weak health status)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombocytopenia (decrease of platelets in blood)
Asthenia (weakness)
Cough
Decreased appetite

40-49:

Dyspnoea (difficult or laboured respiration)
Drug ineffective
Pericardial effusion (fluid around the heart)
Pulmonary embolism (blockage of the main artery of the lung)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Drug eruption (adverse drug reaction of the skin)
Hypokinesia (decreased bodily movement)
Sedation
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Enteritis infectious (infection with feline parvovirus (fpv), also known as feline panleucopenia virus)
Enterococcal infection
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haematocrit decreased
Haemoglobin decreased
Haemorrhage (bleeding)

60+:

Drug ineffective
Lymphocyte count decreased
Monocyte count decreased
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Asthenia (weakness)
Blood albumin decreased
Blood creatinine decreased
Blood urea increased

What are the existing conditions these people have? *

Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 11 people, 12.79%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 9 people, 10.47%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 8 people, 9.30%
Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells): 6 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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