Phoslo and Soliris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phoslo (calcium acetate) and Soliris (eculizumab). Common drug interactions include myoclonus among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Phoslo and Soliris. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Phoslo?

Phoslo has active ingredients of calcium acetate. eHealthMe is studying from 4,291 Phoslo users. Check the latest studies of Phoslo.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

On Aug, 04, 2026

56 people who take Phoslo and Soliris together, and have interactions are studied.

What are the common drug interactions of Phoslo and Soliris, by gender? *:

female:

Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Night sweats (sweating in night)
Oedema peripheral (superficial swelling)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Poor venous access
Rales (an abnormal respiratory sound characterized by fine crackles)

male:

Pneumonia
Asthenia (weakness)
Pain
Peptic ulcer
Thrombosis (formation of a blood clot inside a blood vessel)
Underweight
Urinary tract infection
Vomiting
Cardiomyopathy (weakening of the heart muscle)
Epistaxis (bleed from the nose)

What are the common drug interactions of Phoslo and Soliris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Device related infection
Hypertensive emergency

10-19:

n/a

20-29:

Pneumonia
Haemorrhage (bleeding)
Cardiomyopathy (weakening of the heart muscle)
Epistaxis (bleed from the nose)
Hypervolaemia (abnormally increased volume of blood)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Meningitis enterococcal (fungal inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Paroxysmal nocturnal haemoglobinuria (haemoglobin in the urine)

30-39:

Chest pain
Clostridial infection (infectious conditions by clostridium bacteria)
Coagulopathy (blood's ability to clot is impaired)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Septic shock (shock due to blood infection)
Thrombocytopenia (decrease of platelets in blood)
Viral infection
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pyrexia (fever)

40-49:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Haptoglobin decreased
Infection
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pain
Peptic ulcer

50-59:

Anaemia (lack of blood)
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Death
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Pyrexia (fever)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Complications of transplanted kidney
Deafness unilateral
Nausea (feeling of having an urge to vomit)
Road traffic accident

60+:

Haemoglobin decreased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Cough
Dialysis related complication
Laryngeal oedema (swelling of larynx)
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Throat irritation
Blood pressure decreased

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 36 people, 64.29%
High Blood Pressure: 23 people, 41.07%
Indigestion: 22 people, 39.29%
Hypersensitivity: 17 people, 30.36%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 17 people, 30.36%
Pain: 15 people, 26.79%
Itching: 15 people, 26.79%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 11 people, 19.64%
Addison's Disease (addison's disease, a hormonal disorder disease): 9 people, 16.07%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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