Phoslo and Zestril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Phoslo (calcium acetate) and Zestril (lisinopril). Common drug interactions include muscular weakness among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Phoslo and Zestril. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Phoslo?

Phoslo has active ingredients of calcium acetate. eHealthMe is studying from 4,291 Phoslo users. Check the latest studies of Phoslo.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

On Aug, 09, 2026

86 people who take Phoslo and Zestril together, and have interactions are studied.

What are the common drug interactions of Phoslo and Zestril, by gender? *:

female:

Muscular weakness (muscle weakness)
Scar
Skin discolouration (change of skin colour)
Skin tightness
Anxiety
Pneumonia
Cardiomyopathy (weakening of the heart muscle)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dyspnoea (difficult or laboured respiration)
Hypoaesthesia (reduced sense of touch or sensation)

male:

Renal failure (kidney dysfunction)
Pyrexia (fever)
Drug toxicity
Muscle injury
Myopathy (a muscular disease in which the muscle fibres do not function)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Ejection fraction decreased (systolic heart failure)
Mastication disorder (disease of chewing food)
Migraine (headache)

What are the common drug interactions of Phoslo and Zestril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Cough
Dyspnoea (difficult or laboured respiration)
Idiosyncratic drug reaction (unusual effect of the medication)
Pulmonary congestion (congestion in the lungs)
Anaphylactic reaction (serious allergic reaction)
Blood pressure decreased
Circulatory collapse
Hypotension (abnormally low blood pressure)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

30-39:

Abasia (inability to walk)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Balance disorder
Dry skin
Dysstasia (difficulty in standing)
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Gait disturbance

40-49:

Cardiomyopathy (weakening of the heart muscle)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pneumonia
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Blindness
Blood cholesterol increased
Blood potassium increased
Carotid bruit (sound heard over the carotid artery area during auscultation)

50-59:

Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Emotional distress
Hypoaesthesia (reduced sense of touch or sensation)
Pain
Scar
Skin discolouration (change of skin colour)
Skin tightness
Activities of daily living impaired
Chest pain
Chronic kidney disease

60+:

Pain
Joint contracture (a permanent shortening of a muscle or joint)
Oedema peripheral (superficial swelling)
Pitting oedema (skin discoloration)
Sensory loss (senses loss)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Muscle tightness
Oedema (fluid collection in tissue)
Abasia (inability to walk)
Arthropathy

What are the existing conditions these people have? *

Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 13 people, 15.12%
High Blood Cholesterol: 12 people, 13.95%
Pain: 11 people, 12.79%
Nuclear Magnetic Resonance Imaging Brain: 11 people, 12.79%
Seasonal Allergy (allergic condition due to certain season): 10 people, 11.63%
Insulin Resistance: 10 people, 11.63%
Ill-Defined Disorder: 10 people, 11.63%
Diabetes: 10 people, 11.63%
Anaemia (lack of blood): 9 people, 10.47%
Pneumonia: 8 people, 9.30%

* Approximation only. Some reports may have incomplete information.

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