Pioglitazone hydrochloride and Paroxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pioglitazone hydrochloride (pioglitazone hydrochloride) and Paroxetine (paroxetine hydrochloride). Common drug interactions include dyspnoea among females and ankle fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Pioglitazone hydrochloride and Paroxetine. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Pioglitazone hydrochloride?

Pioglitazone hydrochloride has active ingredients of pioglitazone hydrochloride. eHealthMe is studying from 2,161 Pioglitazone hydrochloride users. Check the latest studies of Pioglitazone hydrochloride.

What is Paroxetine?

Paroxetine has active ingredients of paroxetine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 65,088 Paroxetine users. Check the latest studies of Paroxetine.

On Jul, 16, 2026

18 people who take Pioglitazone hydrochloride and Paroxetine together, and have interactions are studied.

Pioglitazone hydrochloride and Paroxetine drug interactions.

What are the common drug interactions of Pioglitazone Hydrochloride and Paroxetine, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Overdose
Somnolence (a state of near-sleep, a strong desire for sleep)
Tremor (trembling or shaking movements in one or more parts of your body)
Blood glucose increased
Chronic kidney disease
Muscle spasms (muscle contraction)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

male:

Ankle fracture
Blood pressure decreased
Hypoglycaemia (deficiency of glucose in the bloodstream)
Lactic acidosis (low ph in body tissues)
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Pneumonia fungal
Pyrexia (fever)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Suicide attempt
Confusional state

What are the common drug interactions of Pioglitazone Hydrochloride and Paroxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Lactic acidosis (low ph in body tissues)
Suicide attempt

40-49:

n/a

50-59:

Blood glucose increased
Dark circles under eyes
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Disease progression
Dry mouth
Glycosylated haemoglobin increased
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Mucosal inflammation (infection of mucous membrane)

60+:

Dyspnoea (difficult or laboured respiration)
Overdose
Renal impairment (severely reduced kidney function)
Abdominal discomfort
Agitation (state of anxiety or nervous excitement)
Ankle fracture
Arthralgia (joint pain)
Balance disorder
Blood glucose increased
Blood pressure decreased

What are the existing conditions these people have? *

Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 22.22%
High Blood Cholesterol: 3 people, 16.67%
Acidosis (build-up of carbon dioxide in the blood): 2 people, 11.11%
Diabetes: 2 people, 11.11%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 11.11%
High Blood Pressure: 2 people, 11.11%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 11.11%
Infection: 2 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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