Pioglitazone and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pioglitazone (pioglitazone hydrochloride) and Codeine (codeine sulfate). Common drug interactions include rhinitis among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Pioglitazone and Codeine. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Pioglitazone?

Pioglitazone has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 12,864 Pioglitazone users. Check the latest studies of Pioglitazone.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

On Jul, 06, 2026

72 people who take Pioglitazone and Codeine together, and have interactions are studied.

Pioglitazone and Codeine drug interactions.

What are the common drug interactions of Pioglitazone and Codeine, by gender? *:

female:

Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Sensation of foreign body
Sepsis (a severe blood infection that can lead to organ failure and death)
Superinfection bacterial
Weight decreased
Drug hypersensitivity
Fatigue (feeling of tiredness)
Asthenia (weakness)
Chronic kidney disease
Drug ineffective

male:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Abdominal pain
Cellulitis (infection under the skin)
Diarrhoea
Duodenal perforation (complication of duodenal ulcer)
Hyperglycaemia (high blood sugar)

What are the common drug interactions of Pioglitazone and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Purpura (purplish discoloration of the skin)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Alanine aminotransferase increased
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Aspartate aminotransferase increased
Blood urea increased
Gastric mucosal lesion (lesion of stomach mucous membrane)
Infection
Injection site cellulitis (injection site inflammation)

50-59:

Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Drug hypersensitivity
Vomiting
Abdominal discomfort
Abdominal hernia
Abdominal pain upper
Arthralgia (joint pain)
Back disorder
Blood pressure systolic increased
Disease progression
Encephalopathy (functioning of the brain is affected by some agent or condition)

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 13.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 13.89%
Cough: 9 people, 12.50%
Fever: 7 people, 9.72%
Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 6 people, 8.33%
Type 2 Diabetes: 5 people, 6.94%
Nausea (feeling of having an urge to vomit): 5 people, 6.94%
Muscle Spasms (muscle contraction): 5 people, 6.94%
High Blood Cholesterol: 5 people, 6.94%
Diarrhea: 5 people, 6.94%

* Approximation only. Some reports may have incomplete information.

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