Pioglitazone and Compazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pioglitazone (pioglitazone hydrochloride) and Compazine (prochlorperazine maleate). Common drug interactions include asthenia among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Pioglitazone and Compazine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Pioglitazone?

Pioglitazone has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 12,864 Pioglitazone users. Check the latest studies of Pioglitazone.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in indigestion. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

On Jul, 15, 2026

22 people who take Pioglitazone and Compazine together, and have interactions are studied.

Pioglitazone and Compazine drug interactions.

What are the common drug interactions of Pioglitazone and Compazine, by gender? *:

female:

Asthenia (weakness)
Chronic kidney disease
Dehydration (dryness resulting from the removal of water)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Herpes zoster
Malignant peritoneal neoplasm (cancer tumour of peritoneum)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metastases to liver (cancer spreads to liver)
Nephrogenic anaemia (anaemia due to kidney disease)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

male:

Headache (pain in head)
Nephrolithiasis (calculi in the kidneys)
Autoimmune hepatitis
Chills (felling of cold)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Febrile neutropenia (fever with reduced white blood cells)
Hepatic failure (liver failure)
Hyperhidrosis (abnormally increased sweating)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the common drug interactions of Pioglitazone and Compazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

50-59:

n/a

60+:

Nephrolithiasis (calculi in the kidneys)
Back pain
Weight decreased
Asthenia (weakness)
Autoimmune hepatitis
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatic failure (liver failure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Intestinal mass
Irritable bowel syndrome

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 31.82%
Multiple Myeloma (cancer of the plasma cells): 6 people, 27.27%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 22.73%
Nausea (feeling of having an urge to vomit): 5 people, 22.73%
Bone Pain: 3 people, 13.64%
Dyspnea (difficult or laboured breathing): 3 people, 13.64%
Enlarged Prostate: 3 people, 13.64%
Fever: 3 people, 13.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.64%
Renal Cell Carcinoma (a kidney cancer): 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

Do you take Pioglitazone and Compazine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously