Pioglitazone and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pioglitazone (pioglitazone hydrochloride) and Melatonin (melatonin). Common drug interactions include drug dependence among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Pioglitazone and Melatonin. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Pioglitazone?

Pioglitazone has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 12,864 Pioglitazone users. Check the latest studies of Pioglitazone.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Aug, 03, 2026

85 people who take Pioglitazone and Melatonin together, and have interactions are studied.

Pioglitazone and Melatonin drug interactions.

What are the common drug interactions of Pioglitazone and Melatonin, by gender? *:

female:

Drug dependence
Feeling hot
General physical health deterioration (weak health status)
Mania (a state of abnormally elevated or irritable mood)
Neurotransmitter level altered
Pruritus (severe itching of the skin)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Decreased appetite
Drug ineffective

male:

Decreased appetite
Fatigue (feeling of tiredness)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fall
Muscular weakness (muscle weakness)
Pain
Pneumonia
Peripheral swelling

What are the common drug interactions of Pioglitazone and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Agitation (state of anxiety or nervous excitement)
Cerebral disorder (brain disease)
Daydreaming
Drug dependence
Eyelid ptosis (falling of the upper or lower eyelid)
Feeling hot
General physical health deterioration (weak health status)
Headache (pain in head)
Mania (a state of abnormally elevated or irritable mood)
Memory impairment

40-49:

Agitation (state of anxiety or nervous excitement)
Cerebral disorder (brain disease)
Chronic kidney disease
Daydreaming
Drug dependence
Drug ineffective
Feeling hot
General physical health deterioration (weak health status)
Headache (pain in head)
Mania (a state of abnormally elevated or irritable mood)

50-59:

Chest pain
Chills (felling of cold)
Concussion (short loss of normal brain function in response to a head injury)
Constipation
Cough
Coxsackie virus test positive
Discomfort
Dizziness
Dry skin
Dysgeusia (disorder of the sense of taste)

60+:

Decreased appetite
Nausea (feeling of having an urge to vomit)
White blood cell count decreased
Abdominal discomfort
Anxiety
Asthenia (weakness)
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Death
Diarrhoea

What are the existing conditions these people have? *

High Blood Cholesterol: 11 people, 12.94%
Depression: 9 people, 10.59%
High Blood Pressure: 8 people, 9.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 9.41%
Multiple Myeloma (cancer of the plasma cells): 7 people, 8.24%
Blood Glucose Abnormal: 7 people, 8.24%
Type 2 Diabetes: 6 people, 7.06%
Sleep Disorder: 5 people, 5.88%
Pain: 5 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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