Piperacillin and Alprazolam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Piperacillin (piperacillin sodium) and Alprazolam (alprazolam). Common drug interactions include abdominal pain among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Piperacillin and Alprazolam. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Piperacillin?

Piperacillin has active ingredients of piperacillin sodium. eHealthMe is studying from 5,597 Piperacillin users. Check the latest studies of Piperacillin.

What is Alprazolam?

Alprazolam has active ingredients of alprazolam. It is often used in stress and anxiety. eHealthMe is studying from 134,864 Alprazolam users. Check the latest studies of Alprazolam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

68 people who take Piperacillin and Alprazolam together, and have interactions are studied.

Piperacillin and Alprazolam drug interactions.

What are the common drug interactions of Piperacillin and Alprazolam, by gender? *:

female:

Abdominal pain
Alanine aminotransferase increased
Blood alkaline phosphatase increased
Dehydration (dryness resulting from the removal of water)
Gastroenteritis (inflammation of stomach and intestine)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypokalaemia (low potassium)
Malaise (a feeling of general discomfort or uneasiness)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Pneumonia

male:

Pneumonia
Febrile neutropenia (fever with reduced white blood cells)
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatinine increased
Bone marrow failure
Cardiac arrest
Chronic kidney disease
Gamma-glutamyltransferase increased
Renal failure (kidney dysfunction)

What are the common drug interactions of Piperacillin and Alprazolam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood creatinine increased
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Pruritus generalised (generalized itching)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Renal impairment (severely reduced kidney function)

30-39:

White blood cell count decreased
Hemianopia (blindness or reduction in vision in one half of the visual field due to damage of the optic pathways in the brain)
Nausea (feeling of having an urge to vomit)
Skin fissures (a crack in the skin)
Thrombocytopenia (decrease of platelets in blood)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatic enzyme increased
Liver injury

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Gamma-glutamyltransferase increased
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic enzyme increased
Cystitis haemorrhagic (blood in the urine and painful voiding)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Renal tubular necrosis (death of kidney tubules)

50-59:

Renal failure (kidney dysfunction)
Aortitis (inflammation of the aortic wall)
Aspartate aminotransferase increased
Axillary pain
Cough
Decreased appetite
Epigastric discomfort
Gastric ulcer (stomach ulcer)
Gingivitis (inflammation of gums)
Haematocrit decreased

60+:

Decreased appetite
Pneumonia
Anaemia (lack of blood)
Delirium (wild excitement)
Febrile neutropenia (fever with reduced white blood cells)
Gastroenteritis (inflammation of stomach and intestine)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

High Blood Pressure: 12 people, 17.65%
Pain: 11 people, 16.18%
Depression: 9 people, 13.24%
High Blood Cholesterol: 7 people, 10.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 10.29%
Infection: 6 people, 8.82%
Nausea (feeling of having an urge to vomit): 5 people, 7.35%
Sleep Disorder: 4 people, 5.88%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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