Piperacillin and Polaramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Piperacillin (piperacillin sodium) and Polaramine (dexchlorpheniramine maleate). Common drug interactions include febrile neutropenia among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Piperacillin and Polaramine. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Piperacillin?

Piperacillin has active ingredients of piperacillin sodium. eHealthMe is studying from 5,597 Piperacillin users. Check the latest studies of Piperacillin.

What is Polaramine?

Polaramine has active ingredients of dexchlorpheniramine maleate. It is often used in allergic rhinitis. eHealthMe is studying from 10,531 Polaramine users. Check the latest studies of Polaramine.

On Jul, 18, 2026

24 people who take Piperacillin and Polaramine together, and have interactions are studied.

Piperacillin and Polaramine drug interactions.

What are the common drug interactions of Piperacillin and Polaramine, by gender? *:

female:

Febrile neutropenia (fever with reduced white blood cells)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Anaemia (lack of blood)
Decreased appetite
Diarrhoea
Gastric mucosal lesion (lesion of stomach mucous membrane)
Headache (pain in head)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Death
Hyperammonaemia
Pulmonary interstitial emphysema syndrome (collection of gases outside of the normal air passages and inside the connective tissue of the peribronchovascular sheaths, interlobular septa, and visceral pleura of lungs)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rectal haemorrhage (bleeding from anus)
Restlessness (not able to rest)
Thrombocytopenia (decrease of platelets in blood)
Alanine aminotransferase increased
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

What are the common drug interactions of Piperacillin and Polaramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anaemia (lack of blood)
Decreased appetite
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Gastric mucosal lesion (lesion of stomach mucous membrane)
Headache (pain in head)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)
Platelet count decreased

20-29:

n/a

30-39:

Large intestine perforation (hole in large intestine)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Sepsis (a severe blood infection that can lead to organ failure and death)
Small intestinal haemorrhage (bleeding from small intestine)

40-49:

Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Transplant rejection (a transplant material is not worked)

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
Encephalopathy (functioning of the brain is affected by some agent or condition)

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Death
Hyperammonaemia
Pulmonary interstitial emphysema syndrome (collection of gases outside of the normal air passages and inside the connective tissue of the peribronchovascular sheaths, interlobular septa, and visceral pleura of lungs)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rectal haemorrhage (bleeding from anus)
Restlessness (not able to rest)
Thrombocytopenia (decrease of platelets in blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Aspergillus test positive

What are the existing conditions these people have? *

Hypokalemia (low potassium): 4 people, 16.67%
Diarrhea: 4 people, 16.67%
Fever: 4 people, 16.67%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 16.67%
Skin Infection: 4 people, 16.67%
The Flu (the flu is caused by an influenza virus): 2 people, 8.33%
Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 2 people, 8.33%
Headache (pain in head): 2 people, 8.33%
High Blood Pressure: 2 people, 8.33%
Hypersensitivity: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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