Piperacillin and Rifadin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Piperacillin (piperacillin sodium) and Rifadin (rifampin). Common drug interactions include blood bilirubin increased among females and eosinophilia among males.

The phase IV clinical study analyzes what interactions people have when they take Piperacillin and Rifadin. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Piperacillin?

Piperacillin has active ingredients of piperacillin sodium. eHealthMe is studying from 5,597 Piperacillin users. Check the latest studies of Piperacillin.

What is Rifadin?

Rifadin has active ingredients of rifampin. eHealthMe is studying from 2,104 Rifadin users. Check the latest studies of Rifadin.

On Jul, 09, 2026

13 people who take Piperacillin and Rifadin together, and have interactions are studied.

Piperacillin and Rifadin drug interactions.

What are the common drug interactions of Piperacillin and Rifadin, by gender? *:

female:

Blood bilirubin increased
C-reactive protein increased
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Thrombocythaemia (an increased number of platelets in the circulating blood)

male:

Eosinophilia (eosinophil count in the peripheral blood exceeds)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hyperammonaemia
Pulmonary interstitial emphysema syndrome (collection of gases outside of the normal air passages and inside the connective tissue of the peribronchovascular sheaths, interlobular septa, and visceral pleura of lungs)
Rectal haemorrhage (bleeding from anus)
Restlessness (not able to rest)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Pyrexia (fever)

What are the common drug interactions of Piperacillin and Rifadin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Eosinophil count increased
Infection parasitic
Lymphadenopathy (disease or enlargement of lymph nodes)
White blood cell count increased
Cough
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)

40-49:

n/a

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Leukopenia (less number of white blood cells in blood)
Toxic skin eruption (skin breakdown due to toxic substance)

60+:

Death
Diffuse alveolar damage (common manifestation of drug-induced lung injury)
Pulmonary interstitial emphysema syndrome (collection of gases outside of the normal air passages and inside the connective tissue of the peribronchovascular sheaths, interlobular septa, and visceral pleura of lungs)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rectal haemorrhage (bleeding from anus)
Restlessness (not able to rest)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Blood bilirubin increased
C-reactive protein increased

What are the existing conditions these people have? *

Skin Infection: 4 people, 30.77%
Psychotic Disorder: 2 people, 15.38%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.69%
Injury Corneal: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Piperacillin and Rifadin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously