Piperacillin and Xigris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Piperacillin (piperacillin sodium) and Xigris (drotrecogin alfa (activated)). Common drug interactions include grand mal convulsion among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Piperacillin and Xigris. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Piperacillin?

Piperacillin has active ingredients of piperacillin sodium. eHealthMe is studying from 5,597 Piperacillin users. Check the latest studies of Piperacillin.

What is Xigris?

Xigris has active ingredients of drotrecogin alfa (activated). eHealthMe is studying from 3,542 Xigris users. Check the latest studies of Xigris.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

14 people who take Piperacillin and Xigris together, and have interactions are studied.

Piperacillin and Xigris drug interactions.

What are the common drug interactions of Piperacillin and Xigris, by gender? *:

female:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Activated partial thromboplastin time prolonged
Catheter site haemorrhage (bleeding at catheter site)
Coagulopathy (blood's ability to clot is impaired)
Infarction (obstruction of the blood supply to an organ or region of tissue)
Septic shock (shock due to blood infection)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Activated partial thromboplastin time prolonged
Meningococcal sepsis (meningococcal infection to whole body)
Overdose
Renal impairment (severely reduced kidney function)
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Thrombocytopenia (decrease of platelets in blood)
White blood cell count decreased
Blood creatinine decreased

What are the common drug interactions of Piperacillin and Xigris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Respiratory failure (inadequate gas exchange by the respiratory system)

30-39:

n/a

40-49:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Renal impairment (severely reduced kidney function)

50-59:

Activated partial thromboplastin time prolonged
Blood creatinine decreased
Epistaxis (bleed from the nose)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
International normalised ratio increased
Mouth haemorrhage (bleeding from mouth)
Platelet count decreased
White blood cell count decreased
White blood cell count increased

60+:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Overdose
Thrombocytopenia (decrease of platelets in blood)
White blood cell count increased
Septic shock (shock due to blood infection)
Activated partial thromboplastin time prolonged
Anuria (failure of the kidneys to produce urine)
Cardiac arrest
Catheter site haemorrhage (bleeding at catheter site)

What are the existing conditions these people have? *

Sepsis (a severe blood infection that can lead to organ failure and death): 8 people, 57.14%
Sedation: 1 person, 7.14%
Pain: 1 person, 7.14%
Multi-Organ Failure (multisystem organ failure): 1 person, 7.14%
Meningococcal Sepsis (meningococcal infection to whole body): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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