Pirfenidone and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pirfenidone (pirfenidone) and Prograf (tacrolimus). Common drug interactions include dyspnoea among females and herpes zoster among males.

The phase IV clinical study analyzes what interactions people have when they take Pirfenidone and Prograf. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Pirfenidone?

Pirfenidone has active ingredients of pirfenidone. eHealthMe is studying from 2,648 Pirfenidone users. Check the latest studies of Pirfenidone.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 29, 2026

13 people who take Pirfenidone and Prograf together, and have interactions are studied.

Pirfenidone and Prograf drug interactions.

What are the common drug interactions of Pirfenidone and Prograf, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Cough
Chest discomfort
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dyspnoea exertional (breathlessness or shortness of breath)
General physical health deterioration (weak health status)
Heart rate increased
Hypoxia (low oxygen in tissues)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Wheezing (a high-pitched whistling sound made while you breath)

male:

Herpes zoster
Abdominal pain
Blood sodium decreased
C-reactive protein increased
Diarrhoea
Drug level increased
Dyspnoea (difficult or laboured respiration)
Haematocrit decreased
Haemoglobin decreased
Haemoglobin increased

What are the common drug interactions of Pirfenidone and Prograf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dyspnoea (difficult or laboured respiration)

30-39:

n/a

40-49:

n/a

50-59:

Cough
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Hypoxia (low oxygen in tissues)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Transplant rejection (a transplant material is not worked)

60+:

Herpes zoster
Dyspnoea (difficult or laboured respiration)
Blood potassium increased
Blood sodium decreased
C-reactive protein increased
Diarrhoea
Drug level increased
General physical health deterioration (weak health status)
Haematocrit decreased
Haemoglobin decreased

What are the existing conditions these people have? *

Obliterative Bronchiolitis (bronchiolar inflammation): 7 people, 53.85%
Interstitial Lung Disease: 2 people, 15.38%
Tachyarrhythmia (disturbance of the heart rhythm in which the heart rate is abnormally increased): 1 person, 7.69%
Nausea (feeling of having an urge to vomit): 1 person, 7.69%
Ischaemic Stroke (stroke; caused by an interruption in the flow of blood to the brain): 1 person, 7.69%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 1 person, 7.69%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 1 person, 7.69%
Hypersensitivity: 1 person, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.69%
Embolism Venous (embolus may pass into the arterial system): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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