Plaquenil and Ocrevus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Plaquenil (hydroxychloroquine sulfate) and Ocrevus (ocrelizumab). Common drug interactions include eustachian tube dysfunction among females and hypoaesthesia among males.

The phase IV clinical study analyzes what interactions people have when they take Plaquenil and Ocrevus. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.

What is Ocrevus?

Ocrevus has active ingredients of ocrelizumab. eHealthMe is studying from 56,583 Ocrevus users. Check the latest studies of Ocrevus.

On Aug, 04, 2026

47 people who take Plaquenil and Ocrevus together, and have interactions are studied.

Plaquenil and Ocrevus drug interactions.

What are the common drug interactions of Plaquenil and Ocrevus, by gender? *:

female:

Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Fracture
Gangrene (body tissue dies)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Fatigue (feeling of tiredness)
Headache (pain in head)
Rhinorrhoea (watery mucus discharge from the nose)
Gait disturbance
Drug ineffective
Lacrimation increased

male:

Hypoaesthesia (reduced sense of touch or sensation)
Throat irritation
Pain
Aptyalism (deficiency or absence of saliva)
Blood cholesterol increased
Dry eye (lack of adequate tears)
Fatigue (feeling of tiredness)
Therapeutic response decreased (less preventive response)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure increased

What are the common drug interactions of Plaquenil and Ocrevus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cerebral artery stenosis (hardening of brain blood vessels)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Chest pain
Chronic kidney disease
Depression
Dilated cardiomyopathy
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Ejection fraction decreased (systolic heart failure)

30-39:

Hypoaesthesia (reduced sense of touch or sensation)
Throat irritation
Abscess limb (limb infection)
Aptyalism (deficiency or absence of saliva)
Blood cholesterol increased
Dry eye (lack of adequate tears)
Fatigue (feeling of tiredness)
Therapeutic response decreased (less preventive response)
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)

40-49:

Choking sensation (feeling of obstruction in respiratory system)
Headache (pain in head)
Hypertension (high blood pressure)
Influenza
Infusion related reaction
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rash pruritic (redness with itching)
Throat irritation

50-59:

Fatigue (feeling of tiredness)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Ear pain
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Lymphadenopathy (disease or enlargement of lymph nodes)
Night sweats (sweating in night)
Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
Pruritus (severe itching of the skin)
Sinus headache (headache caused by sinus infections)

60+:

Memory impairment
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Gait disturbance
Seasonal allergy (allergic condition due to certain season)
Tooth extraction
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urinary tract infection
Weight decreased
Asthenia (weakness)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 20 people, 42.55%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 23.40%
Immunodeficiency: 9 people, 19.15%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 12.77%
Muscle Spasms (muscle contraction): 5 people, 10.64%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 5 people, 10.64%
Headache (pain in head): 5 people, 10.64%
High Blood Cholesterol: 4 people, 8.51%
Joint Pain: 4 people, 8.51%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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