Plaquenil and Premphase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Plaquenil (hydroxychloroquine sulfate) and Premphase (estrogens, conjugated; medroxyprogesterone acetate). Common drug interactions include convulsion among females.

The phase IV clinical study analyzes what interactions people have when they take Plaquenil and Premphase. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,019 Plaquenil users. Check the latest studies of Plaquenil.

What is Premphase?

Premphase has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 2,262 Premphase users. Check the latest studies of Premphase.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

22 people who take Plaquenil and Premphase together, and have interactions are studied.

Plaquenil and Premphase drug interactions.

What are the common drug interactions of Plaquenil and Premphase, by gender? *:

female:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Mitral valve incompetence (inefficient heart valve)
Arthropathy
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dyspnoea (difficult or laboured respiration)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

male:

n/a

What are the common drug interactions of Plaquenil and Premphase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dry mouth
Enuresis (repeated inability to control urination)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Visual field defect
Weight decreased
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Brain neoplasm (tumour of brain)

40-49:

Cystitis interstitial (unknown cause characterized by bladder pain)
Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Genital pain (pain in genital)
Herpes zoster
Hypokalaemia (low potassium)
Injury
Insomnia (sleeplessness)
Oedema (fluid collection in tissue)

50-59:

Nausea (feeling of having an urge to vomit)
Abdominal distension
Areflexia (absence of a reflex)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dyspepsia (indigestion)
Eructation (release of gas from the digestive tract)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)

60+:

Blood pressure increased
Breast cancer female
Weight decreased
Chills (felling of cold)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Erythema (redness of the skin)
Infusion related reaction
Pyrexia (fever)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 31.82%
Shoulder Pain: 4 people, 18.18%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 18.18%
High Blood Cholesterol: 3 people, 13.64%
Pain: 2 people, 9.09%
Osteoporosis (bones weak and more likely to break): 2 people, 9.09%
Growth Hormone Deficiency: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Plaquenil and Premphase?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously