Plaquenil and Propulsid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Plaquenil (hydroxychloroquine sulfate) and Propulsid (cisapride monohydrate). Common drug interactions include pyrexia among females and acute coronary syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Plaquenil and Propulsid. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.

What is Propulsid?

Propulsid has active ingredients of cisapride monohydrate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 8,130 Propulsid users. Check the latest studies of Propulsid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

31 people who take Plaquenil and Propulsid together, and have interactions are studied.

Plaquenil and Propulsid drug interactions.

What are the common drug interactions of Plaquenil and Propulsid, by gender? *:

female:

Pyrexia (fever)
Short-term memory loss
Sinus congestion (blockage of sinus)
Sinusitis (inflammation of sinus)
Skin necrosis (skin damage)
Spondylitis (an inflammation of the vertebra with spinal cord involvement)
Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
Trance
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Tremor (trembling or shaking movements in one or more parts of your body)

male:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Intermittent claudication
Iron deficiency anaemia
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pancreatitis (inflammation of pancreas)
Renal injury (kidney injury)
Skin injury
Thrombosis (formation of a blood clot inside a blood vessel)

What are the common drug interactions of Plaquenil and Propulsid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)
Chest tightness
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Injection site abscess
Nausea (feeling of having an urge to vomit)
Neck pain
Oesophageal stenosis (narrowing of oesophagus)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Psychotic disorder
Pyrexia (fever)
Short-term memory loss
Sinus congestion (blockage of sinus)

50-59:

Electrocardiogram qt prolonged
Gastroenteritis helicobacter (inflammation of stomach and intestine caused by helicobacter infection)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Chest pain
Oesophageal reflux (moving the food downwards)
Pain
Weight decreased
Abdominal pain
Asthma
Ataxia (loss of full control of bodily movements)

60+:

Chest pain
Electrocardiogram qt prolonged
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder disorder
Headache (pain in head)
Hepatocellular damage (liver damage)
Hypoxia (low oxygen in tissues)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Intermittent claudication
Iron deficiency anaemia

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 12.90%
Asthma: 3 people, 9.68%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 9.68%
Dry Eyes (lack of adequate tears): 3 people, 9.68%
Gastrointestinal Motility Disorder (abnormal intestinal contractions): 3 people, 9.68%
Upper Respiratory Tract Infection: 2 people, 6.45%
Folliculitis (infection of hair root): 2 people, 6.45%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 6.45%
Dyspnea (difficult or laboured breathing): 2 people, 6.45%
Eye Inflammation: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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