Plaquenil and Vancomycin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Plaquenil (hydroxychloroquine sulfate) and Vancomycin (vancomycin). Common drug interactions include synovitis among females and double stranded dna antibody positive among males.

The phase IV clinical study analyzes what interactions people have when they take Plaquenil and Vancomycin. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,019 Plaquenil users. Check the latest studies of Plaquenil.

What is Vancomycin?

Vancomycin has active ingredients of vancomycin. eHealthMe is studying from 17,165 Vancomycin users. Check the latest studies of Vancomycin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

64 people who take Plaquenil and Vancomycin together, and have interactions are studied.

Plaquenil and Vancomycin drug interactions.

What are the common drug interactions of Plaquenil and Vancomycin, by gender? *:

female:

Synovitis (inflammation of the synovial membrane)
Bone erosion
Tooth disorder (tooth disease)
Pain in extremity
Arthralgia (joint pain)
Body temperature decreased
Cough
Fatigue (feeling of tiredness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Chest pain

male:

Double stranded dna antibody positive
Haemoglobin decreased
Foetal growth restriction (poor growth of a baby while in the mother's womb during pregnancy)
Hepatitis acute
Low birth weight baby
Maternal exposure before pregnancy (use of substance before pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Premature baby
Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age)

What are the common drug interactions of Plaquenil and Vancomycin, by age (0-1 to 60+)? *:

0-1:

Foetal growth restriction (poor growth of a baby while in the mother's womb during pregnancy)
Low birth weight baby
Maternal exposure before pregnancy (use of substance before pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Premature baby
Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age)
Developmental delay

2-9:

n/a

10-19:

n/a

20-29:

Double stranded dna antibody positive
Haemoglobin decreased
Headache (pain in head)
Pyrexia (fever)
Rash
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
White blood cell count decreased
Protein urine
Cough
Therapeutic response decreased (less preventive response)

30-39:

Blood sodium decreased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chest pain
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Dyspnoea (difficult or laboured respiration)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Headache (pain in head)
Influenza
Infusion site bruising
Infusion site haemorrhage (bleeding from infusion site)

40-49:

Hepatitis acute
Abscess limb (limb infection)
Cellulitis (infection under the skin)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nerve injury
Pain
Perirectal abscess
Rectal abscess (pus in rectum)
Scar
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Aspartate aminotransferase increased
Asthenia (weakness)
Asthma
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood parathyroid hormone decreased
Blood pressure decreased
Body temperature decreased
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
C-reactive protein increased

60+:

Infusion related reaction
Blood pressure increased
Depression
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Endometrial disorder
Enterococcus test positive
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Gamma-glutamyltransferase increased
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Heart rate increased

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 32 people, 50.00%
Enterococcal Infection: 26 people, 40.62%
Generalised Oedema (swelling all over the body): 25 people, 39.06%
Pain: 7 people, 10.94%
Sleep Disorder: 4 people, 6.25%
Nausea (feeling of having an urge to vomit): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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