Plavix and Meridia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Plavix (clopidogrel bisulfate) and Meridia (sibutramine hydrochloride). Common drug interactions include pain in extremity among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Plavix and Meridia. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Plavix?

Plavix has active ingredients of clopidogrel bisulfate. It is often used in stent. eHealthMe is studying from 151,179 Plavix users. Check the latest studies of Plavix.

What is Meridia?

Meridia has active ingredients of sibutramine hydrochloride. It is often used in weight loss. eHealthMe is studying from 6,939 Meridia users. Check the latest studies of Meridia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

16 people who take Plavix and Meridia together, and have interactions are studied.

What are the common drug interactions of Plavix and Meridia, by gender? *:

female:

Pain in extremity
Back pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dyspnoea (difficult or laboured respiration)
Depression
Fatigue (feeling of tiredness)
Headache (pain in head)
Acute sinusitis
Arthralgia (joint pain)
Arthropod sting (arthropod bite)

male:

Blood pressure increased
Insomnia (sleeplessness)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder disorder
Iliac artery thrombosis (obstruction of a blood vessel by a blood clot in iliac artery)
Lipids increased (excess lipid in body)
Low density lipoprotein increased (cholesterol increased in blood)
Oedematous pancreatitis (interstitial inflammation and swelling of pancreas)
Pancreatic disorder
Pulmonary embolism (blockage of the main artery of the lung)

What are the common drug interactions of Plavix and Meridia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Crying
Depression
Feeling hot
Insomnia (sleeplessness)
Nervousness

40-49:

Cholecystitis (infection of gallbladder)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder disorder
Iliac artery thrombosis (obstruction of a blood vessel by a blood clot in iliac artery)
Pulmonary embolism (blockage of the main artery of the lung)

50-59:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dyspnoea (difficult or laboured respiration)
Acute sinusitis
Arthropod sting (arthropod bite)
Back pain
Blood glucose decreased
Blood pressure increased
Cardiac disorder
Chest pain
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Arthralgia (joint pain)
Blood pressure increased
Hypophagia (reduced food intake)
Malaise (a feeling of general discomfort or uneasiness)
Pain in limb
Renal failure (kidney dysfunction)
Sluggishness (lacking alertness)
Unexpected therapeutic effect
Venous occlusion (the blocking of venous return)
Anaemia (lack of blood)

What are the existing conditions these people have? *

Weight Loss: 3 people, 18.75%
Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 3 people, 18.75%
High Blood Pressure: 2 people, 12.50%
Depression: 2 people, 12.50%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 12.50%
Weight Decreased: 1 person, 6.25%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 6.25%
Pain: 1 person, 6.25%
Oedema (fluid collection in tissue): 1 person, 6.25%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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