Plavix and Unisom drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Plavix (clopidogrel bisulfate) and Unisom (doxylamine succinate). Common drug interactions include chronic kidney disease among females and coronary artery insufficiency among males.

The phase IV clinical study analyzes what interactions people have when they take Plavix and Unisom. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Plavix?

Plavix has active ingredients of clopidogrel bisulfate. It is often used in stent. eHealthMe is studying from 151,178 Plavix users. Check the latest studies of Plavix.

What is Unisom?

Unisom has active ingredients of doxylamine succinate. It is often used in insomnia. eHealthMe is studying from 3,875 Unisom users. Check the latest studies of Unisom.

On Jul, 06, 2026

28 people who take Plavix and Unisom together, and have interactions are studied.

What are the common drug interactions of Plavix and Unisom, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Pain in extremity
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Back pain
Blood cholesterol increased
Cardiac murmur (an heart sound in valve abnormality)
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Coronary artery insufficiency (insufficiency of artery to carry blood to heart)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Non-cardiac chest pain
Pulmonary congestion (congestion in the lungs)
Anxiety
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood chloride decreased
Blood glucose increased

What are the common drug interactions of Plavix and Unisom, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Benign prostatic hyperplasia (benign enlargement of the prostate)
Drug ineffective
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Ligament rupture (tear in ligament)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Tendon rupture (tear of tendon)
Visual impairment

50-59:

Coronary artery insufficiency (insufficiency of artery to carry blood to heart)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Chronic kidney disease
Renal failure (kidney dysfunction)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cardiomegaly (increased size of heart than normal)
Death
Dyspepsia (indigestion)
Hepatic steatosis (fatty liver disease)
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)

60+:

Pain in extremity
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Peripheral circulatory failure
Psoriasis (immune-mediated disease that affects the skin)
Renal injury (kidney injury)
Varicose vein (veins that have become enlarged and tortuous)
Weight decreased
Angina pectoris (chest pain due to ischemia of the heart muscle)
Metastatic renal cell carcinoma (spreadable kidney cell tumour)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 19 people, 67.86%
High Blood Cholesterol: 11 people, 39.29%
High Blood Pressure: 9 people, 32.14%
Psoriasis (immune-mediated disease that affects the skin): 8 people, 28.57%
Back Pain: 7 people, 25.00%
Abscess (pus): 6 people, 21.43%
Tobacco Withdrawal Symptoms: 6 people, 21.43%
Suicide Attempt: 6 people, 21.43%
Agitation (state of anxiety or nervous excitement): 6 people, 21.43%
Hand Fracture: 6 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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