Plegridy and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Plegridy (peginterferon beta-1a) and Provigil (modafinil). Common drug interactions include skin warm among females and deafness among males.

The phase IV clinical study analyzes what interactions people have when they take Plegridy and Provigil. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Plegridy?

Plegridy has active ingredients of peginterferon beta-1a. eHealthMe is studying from 14,764 Plegridy users. Check the latest studies of Plegridy.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

On Jul, 26, 2026

68 people who take Plegridy and Provigil together, and have interactions are studied.

Plegridy and Provigil drug interactions.

What are the common drug interactions of Plegridy and Provigil, by gender? *:

female:

Skin warm
Swelling face
Thrombosis (formation of a blood clot inside a blood vessel)
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)
Death
Activities of daily living impaired
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Pulmonary thrombosis (scarring in the lungs)
Injection site pruritus (severe itching at injection site)
Abdominal hernia

male:

Deafness
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Influenza like illness
Leukopenia (less number of white blood cells in blood)
Loss of consciousness
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Thrombocytopenia (decrease of platelets in blood)
Abdominal hernia
Balance disorder

What are the common drug interactions of Plegridy and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pain
Headache (pain in head)
Asthenia (weakness)
Blindness
Chest pain
Chills (felling of cold)
Crest syndrome (thick, dry and fibrous skin)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug intolerance (drug sensitivity)
Dyspnoea (difficult or laboured respiration)

50-59:

Dysphagia (a condition in which swallowing is difficult or painful)
Gastric bypass
Hypersensitivity
Immune thrombocytopenic purpura (destruction of blood platelets due to the presence of antiplatelet auto antibodies)
Kidney infection
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Nasopharyngitis (inflammation of the nasopharynx)
Nephrolithiasis (calculi in the kidneys)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Headache (pain in head)

60+:

Thrombosis (formation of a blood clot inside a blood vessel)
Pulmonary thrombosis (scarring in the lungs)
Influenza like illness
Leukopenia (less number of white blood cells in blood)
Loss of consciousness
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pyrexia (fever)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 61 people, 89.71%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 7 people, 10.29%
Muscle Spasms (muscle contraction): 7 people, 10.29%
Pain: 5 people, 7.35%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 4 people, 5.88%
Indigestion: 4 people, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.88%
Gait Disturbance: 4 people, 5.88%
Fatigue (feeling of tiredness): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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