Polyethylene glycol 3350 and Colace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Polyethylene glycol 3350 (polyethylene glycol 3350) and Colace (docusate ). Common drug interactions include bone pain among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Polyethylene glycol 3350 and Colace. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Polyethylene glycol 3350?

Polyethylene glycol 3350 has active ingredients of polyethylene glycol 3350. It is often used in constipation. eHealthMe is studying from 4,407 Polyethylene glycol 3350 users. Check the latest studies of Polyethylene glycol 3350.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.



On Jul, 12, 2026

100 people who take Polyethylene glycol 3350 and Colace together, and have interactions are studied.

Polyethylene glycol 3350 and Colace drug interactions.

What are the common drug interactions of Polyethylene Glycol 3350 and Colace, by gender? *:

female:

  1. Bone pain
  2. Contusion (a type of hematoma of tissue in which capillaries)
  3. Epistaxis (bleed from the nose)
  4. Heart rate decreased
  5. Injection site swelling
  6. Limb discomfort (discomfort in leg)
  7. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  8. Rash papular (redness with papule)
  9. Death
  10. Urinary tract infection

male:

  1. Chronic kidney disease
  2. Osteonecrosis (death of bone)
  3. Plasma cell myeloma (cancer that begins in plasma cells)
  4. Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
  5. Tooth injury
  6. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  7. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  8. Troponin increased
  9. Altered state of consciousness (altered state of mind)
  10. Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Polyethylene Glycol 3350 and Colace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Bacteraemia (presence of bacteria in the blood)
  2. Encephalopathy (functioning of the brain is affected by some agent or condition)
  3. Generalised oedema (swelling all over the body)
  4. Large intestinal ulcer
  5. Cardiac arrest
  6. Colitis (inflammation of colon)
  7. Fungaemia (fungi circulate in the blood)
  8. Left ventricular dysfunction
  9. Sepsis (a severe blood infection that can lead to organ failure and death)
  10. Angiodysplasia (small vascular malformation of the gut)

20-29:

  1. Disturbance in attention
  2. Drug intolerance (drug sensitivity)
  3. Fluid retention (an abnormal accumulation of fluid in the blood)
  4. Somnolence (a state of near-sleep, a strong desire for sleep)
  5. Acne (skin problems that cause pimples)
  6. Adverse drug reaction
  7. Aggression
  8. Depressive symptom
  9. Drug ineffective
  10. Fatigue (feeling of tiredness)

30-39:

  1. Stomatitis (inflammation of mucous membrane of mouth)
  2. Oral herpes (viral infection of mouth)

40-49:

  1. Fatigue (feeling of tiredness)
  2. Infusion related reaction
  3. Muscular weakness (muscle weakness)
  4. Fall
  5. Pain in extremity
  6. Anxiety
  7. Asthenia (weakness)
  8. Back pain
  9. Balance disorder
  10. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

50-59:

  1. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  2. Nasopharyngitis (inflammation of the nasopharynx)
  3. Rash papular (redness with papule)
  4. Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
  5. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
  6. Pyrexia (fever)
  7. Small intestinal obstruction (blockage in small intestine)
  8. Urinary tract infection
  9. Vomiting
  10. Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)

60+:

  1. Nausea (feeling of having an urge to vomit)
  2. Diarrhoea
  3. Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
  4. Dizziness
  5. Gait disturbance
  6. Vomiting
  7. Abdominal discomfort
  8. Abdominal pain lower
  9. Abdominal pain upper
  10. Anal fissure

What are the existing conditions these people have? *

  1. Pain: 9 people, 9.00%
  2. Insomnia (sleeplessness): 9 people, 9.00%
  3. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 8 people, 8.00%
  4. Nausea (feeling of having an urge to vomit): 7 people, 7.00%
  5. High Blood Pressure: 6 people, 6.00%
  6. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 6.00%
  7. Stress And Anxiety: 5 people, 5.00%
  8. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 5 people, 5.00%
  9. Itching: 5 people, 5.00%
  10. Indigestion: 5 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Polyethylene glycol 3350 and Colace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Polyethylene glycol 3350:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Colace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Polyethylene glycol 3350 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Colace and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on polyethylene glycol 3350 and docusate (the active ingredients of Polyethylene glycol 3350 and Colace, respectively), and Polyethylene glycol 3350 and Colace (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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