Polytrim and Durezol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Polytrim (polymyxin b sulfate; trimethoprim sulfate) and Durezol (difluprednate). Common drug interactions include glaucoma among females and bronchitis among males.

The phase IV clinical study analyzes what interactions people have when they take Polytrim and Durezol. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Polytrim?

Polytrim has active ingredients of polymyxin b sulfate; trimethoprim sulfate. eHealthMe is studying from 376 Polytrim users. Check the latest studies of Polytrim.

What is Durezol?

Durezol has active ingredients of difluprednate. It is often used in uveitis. eHealthMe is studying from 3,441 Durezol users. Check the latest studies of Durezol.

On Jul, 06, 2026

15 people who take Polytrim and Durezol together, and have interactions are studied.

What are the common drug interactions of Polytrim and Durezol, by gender? *:

female:

Glaucoma (increased fluid pressure in the eye with vision loss)
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Optic disc haemorrhage (bleeding from optic disc)
Abdominal pain upper
Anaemia (lack of blood)
Asthenia (weakness)
Corneal deposits
Discomfort
Drug ineffective
Dyspnoea (difficult or laboured respiration)

male:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Decreased appetite
Nail infection
Onychomadesis (a periodic idiopathic shedding of the nails)
Pruritus (severe itching of the skin)
Rash
Sinusitis (inflammation of sinus)
Skin disorder (skin disease)
Cataract (clouding of the lens inside the eye)
Endophthalmitis (inflammation of the internal coats of the eye)

What are the common drug interactions of Polytrim and Durezol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Cataract (clouding of the lens inside the eye)

60+:

Glaucoma (increased fluid pressure in the eye with vision loss)
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Eyelid pain
Hypersensitivity
Intraocular pressure increased
Pain
Retinopathy hypertensive (acute damage to the retina of the eye due to high blood pressure)
Throat irritation
Yellow skin
Optic disc haemorrhage (bleeding from optic disc)

What are the existing conditions these people have? *

Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 4 people, 26.67%
Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 13.33%
Dry Eyes (lack of adequate tears): 2 people, 13.33%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 2 people, 13.33%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 2 people, 13.33%
Ocular Hyperaemia (an abnormally large amount of blood in eye): 1 person, 6.67%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 6.67%
Intraocular Pressure Increased: 1 person, 6.67%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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