Polytrim and Senna drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Polytrim (polymyxin b sulfate; trimethoprim sulfate) and Senna (senna). Common drug interactions include eyelid cyst among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Polytrim and Senna. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Polytrim?

Polytrim has active ingredients of polymyxin b sulfate; trimethoprim sulfate. eHealthMe is studying from 376 Polytrim users. Check the latest studies of Polytrim.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

15 people who take Polytrim and Senna together, and have interactions are studied.

What are the common drug interactions of Polytrim and Senna, by gender? *:

female:

Eyelid cyst
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypertension (high blood pressure)
Insomnia (sleeplessness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Transaminases increased
Urinary tract infection
Confusional state

male:

Chronic kidney disease
Fall

What are the common drug interactions of Polytrim and Senna, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Drug effect decreased
Headache (pain in head)
Insomnia (sleeplessness)
Chronic kidney disease

60+:

Asthenia (weakness)
Eye swelling
Eyelid cyst
Fall
Fatigue (feeling of tiredness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Transaminases increased
Urinary tract infection

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 40.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 20.00%
Cough: 2 people, 13.33%
Skin Cancer: 1 person, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%
Abnormal Faeces (abnormal stool): 1 person, 6.67%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 6.67%
Circadian Rhythm Sleep Disorder (family of sleep disorders affecting, among other things, the timing of sleep): 1 person, 6.67%
Insomnia (sleeplessness): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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