Potassium bicarbonate and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Potassium bicarbonate (potassium) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include anaemia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Potassium bicarbonate and Bactrim. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Potassium bicarbonate?

Potassium bicarbonate has active ingredients of potassium. eHealthMe is studying from 453 Potassium bicarbonate users. Check the latest studies of Potassium bicarbonate.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

17 people who take Potassium bicarbonate and Bactrim together, and have interactions are studied.

Potassium bicarbonate and Bactrim drug interactions.

What are the common drug interactions of Potassium Bicarbonate and Bactrim, by gender? *:

female:

Anaemia (lack of blood)
Blood creatinine increased
Blood lactate dehydrogenase increased
Cardiac failure
Circulatory collapse
Conjunctivitis (pink eye)
Constipation
Cryptococcosis (potentially fatal fungal disease)
Gamma-glutamyltransferase increased
Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood)

male:

Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Confusional state
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Cellulitis (infection under the skin)
Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Potassium Bicarbonate and Bactrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Confusional state
Cough
Dysphonia (speech disorder attributable to a disorder of phonation)
Headache (pain in head)
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Oropharyngeal pain
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

50-59:

Anaemia (lack of blood)
Chronic kidney disease
Cryptococcosis (potentially fatal fungal disease)
Dyspnoea (difficult or laboured respiration)
Gout (uric acid crystals building up in the body)
Hypokalaemia (low potassium)
Nephrogenic anaemia (anaemia due to kidney disease)
Oedema (fluid collection in tissue)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

60+:

Blood creatinine increased
Blood lactate dehydrogenase increased
Rash
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
Neuropathy peripheral (surface nerve damage)
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Cardiac failure
Circulatory collapse
Conjunctivitis (pink eye)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 10 people, 58.82%
High Blood Pressure: 9 people, 52.94%
Pain: 7 people, 41.18%
Nausea And Vomiting: 7 people, 41.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 29.41%
Fungal Infection: 5 people, 29.41%
Fever: 5 people, 29.41%
Hypokalemia (low potassium): 5 people, 29.41%
Infection: 5 people, 29.41%
Cardiac Failure: 5 people, 29.41%

* Approximation only. Some reports may have incomplete information.

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