Pradaxa and Enablex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pradaxa (dabigatran etexilate mesylate) and Enablex (darifenacin hydrobromide). Common drug interactions include contusion among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Pradaxa and Enablex. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Pradaxa?

Pradaxa has active ingredients of dabigatran etexilate mesylate. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 86,906 Pradaxa users. Check the latest studies of Pradaxa.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

53 people who take Pradaxa and Enablex together, and have interactions are studied.

What are the common drug interactions of Pradaxa and Enablex, by gender? *:

female:

Contusion (a type of hematoma of tissue in which capillaries)
Dementia (madness)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Dizziness
Drug ineffective
Drug intolerance (drug sensitivity)
Face crushing
Facial bones fracture (bone fracture of face)
Fear
Flatulence (flatus expelled through the anus)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Anaemia (lack of blood)
Flatulence (flatus expelled through the anus)
Rash
Rectal discharge (discharge from rectum)
Rectal haemorrhage (bleeding from anus)
Acute myocardial infarction (acute heart attack)
Cardiac failure congestive
Chronic gastritis (long lasting infection of stomach lining)
Colonic polyp (extra part of colon tissue grow in intestine)

What are the common drug interactions of Pradaxa and Enablex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nephropathy (damage to or disease of a kidney)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Pulmonary thrombosis (scarring in the lungs)

40-49:

n/a

50-59:

n/a

60+:

Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Nausea (feeling of having an urge to vomit)
Pneumonia
Diarrhoea
Flatulence (flatus expelled through the anus)

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 18.87%
Bladder Disorder: 7 people, 13.21%
Incontinence (lack of moderation or self-control): 6 people, 11.32%
Pain: 4 people, 7.55%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 5.66%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.66%
High Blood Cholesterol: 3 people, 5.66%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.66%
Depression: 3 people, 5.66%
Constipation: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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