Pramine and Bextra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pramine (imipramine hydrochloride) and Bextra (valdecoxib). Common drug interactions include sleep apnoea syndrome among females and blood pressure decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Pramine and Bextra. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

30 people who take Pramine and Bextra together, and have interactions are studied.

What are the common drug interactions of Pramine and Bextra, by gender? *:

female:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Abdominal pain
Abnormal behaviour
Acne (skin problems that cause pimples)
Aggression
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Apnoea (suspension of external breathing)
Breast cancer female
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

male:

Blood pressure decreased
Blood pressure increased
Memory impairment
Panic attack
Renal disorder (kidney disease)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tooth extraction
Visual acuity reduced (reduced clearness of vision)
Toothache (tooth pain)
Hypertension (high blood pressure)

What are the common drug interactions of Pramine and Bextra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood pressure decreased
Blood pressure increased
Candidiasis (candidiasis or thrush is a fungal infection)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Dysuria (painful or difficult urination)
Hyperglycaemia (high blood sugar)
Hypoaesthesia (reduced sense of touch or sensation)

40-49:

Aggression
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Chest pain
Constipation
Depression
Drug effect decreased
Dry mouth
Excoriation (to tear or wear off the skin of)
Headache (pain in head)
Hemiparesis (weakness on one side of the body)

50-59:

Vitamin b12 decreased
Asthma
Blood triglycerides increased
Body height decreased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Fibromyalgia (a long-term condition which causes pain all over the body)
Memory impairment
Tendonitis (a condition that causes pain and swelling of tendons)
Breast cancer
Neuropathy peripheral (surface nerve damage)

60+:

Abscess jaw (tooth abscess or root abscess)
Anaemia (lack of blood)
Intestinal obstruction
Limb injury
Obesity (having too much body fat)
Oedema peripheral (superficial swelling)
Oral pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteomyelitis (infection of bone)
Panic disorder

What are the existing conditions these people have? *

Breast Cancer: 13 people, 43.33%
Bone Pain: 12 people, 40.00%
Depression: 4 people, 13.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 10.00%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 3 people, 10.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.67%
Oesophageal Candidiasis (fungal infection of oesophagus): 2 people, 6.67%
Intervertebral Disc Protrusion (spinal disc protrusion): 2 people, 6.67%
Ill-Defined Disorder: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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