Pramine and Protamine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pramine (imipramine hydrochloride) and Protamine sulfate (protamine sulfate). Common drug interactions include anxiety among females and activated partial thromboplastin time prolonged among males.

The phase IV clinical study analyzes what interactions people have when they take Pramine and Protamine sulfate. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

What is Protamine sulfate?

Protamine sulfate has active ingredients of protamine sulfate. eHealthMe is studying from 3,292 Protamine sulfate users. Check the latest studies of Protamine sulfate.

On Jul, 14, 2026

11 people who take Pramine and Protamine sulfate together, and have interactions are studied.

Pramine and Protamine sulfate drug interactions.

What are the common drug interactions of Pramine and Protamine Sulfate, by gender? *:

female:

Anxiety
Emotional distress
Fear
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Stress
Anaemia (lack of blood)
Blood creatinine increased

male:

Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Contusion (a type of hematoma of tissue in which capillaries)
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Epigastric discomfort
Gait disturbance
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Pramine and Protamine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Anxiety
Emotional distress
Fear
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Stress
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Injury

60+:

Anaemia (lack of blood)
Blood creatinine increased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Bacteraemia (presence of bacteria in the blood)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Blood chloride decreased
Blood glucose increased
Body temperature decreased
Catheter site haemorrhage (bleeding at catheter site)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 5 people, 45.45%
Pain: 4 people, 36.36%
Muscle Spasms (muscle contraction): 3 people, 27.27%
Constipation: 3 people, 27.27%
Stress And Anxiety: 1 person, 9.09%
Neoplasm Malignant (cancer tumour): 1 person, 9.09%
Metastases To Bone (cancer spreads to bone): 1 person, 9.09%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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