Pramine and Tacrolimus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pramine (imipramine hydrochloride) and Tacrolimus (tacrolimus). Common drug interactions include blood creatinine increased among females and congestive cardiomyopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Pramine and Tacrolimus. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

What is Tacrolimus?

Tacrolimus has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 116,160 Tacrolimus users. Check the latest studies of Tacrolimus.

On Jul, 23, 2026

14 people who take Pramine and Tacrolimus together, and have interactions are studied.

Pramine and Tacrolimus drug interactions.

What are the common drug interactions of Pramine and Tacrolimus, by gender? *:

female:

Blood creatinine increased
Blood potassium decreased
Blood potassium increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Cytomegalovirus infection
Diarrhoea
Gastroenteritis (inflammation of stomach and intestine)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Proteinuria (presence of protein in the urine)

male:

Congestive cardiomyopathy (weakening of heart muscle)
Diastolic dysfunction
Dyspnoea exertional (breathlessness or shortness of breath)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Systolic dysfunction (impaired ventricular contraction)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the common drug interactions of Pramine and Tacrolimus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Congestive cardiomyopathy (weakening of heart muscle)
Diastolic dysfunction
Dyspnoea exertional (breathlessness or shortness of breath)
Systolic dysfunction (impaired ventricular contraction)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Blood potassium increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Cytomegalovirus infection
Diarrhoea
Gastroenteritis (inflammation of stomach and intestine)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Proteinuria (presence of protein in the urine)
Bacterial test positive
Blood creatinine increased

60+:

Muscular weakness (muscle weakness)
Pain in extremity
Aspartate aminotransferase increased
Back pain
Blood glucose increased
Blood urea increased
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 35.71%
Asthma: 4 people, 28.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 21.43%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 21.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 21.43%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 21.43%
Hypersensitivity: 3 people, 21.43%
Mania (a state of abnormally elevated or irritable mood): 2 people, 14.29%
Malaria (a parasitic disease due to mosquito bite): 2 people, 14.29%
Cardiac Disorder: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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