Pramine and Valacyclovir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pramine (imipramine hydrochloride) and Valacyclovir (valacyclovir hydrochloride). Common drug interactions include cytokine release syndrome among females and cytokine release syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Pramine and Valacyclovir. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

On Jul, 19, 2026

44 people who take Pramine and Valacyclovir together, and have interactions are studied.

Pramine and Valacyclovir drug interactions.

What are the common drug interactions of Pramine and Valacyclovir, by gender? *:

female:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Completed suicide (act of taking one's own life)
Abscess intestinal (collections of pus-intestinal)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Streptococcal sepsis (whole body inflammation by streptococcal)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Therapeutic response unexpected

male:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Abdominal discomfort
Linear iga disease (a rare, idiopathic or drug-induced autoimmune blistering disease of skin)
Local swelling (swelling at the site of some application of substance or injury)
Lymphoedema (localized fluid retention and tissue swelling)
Malaise (a feeling of general discomfort or uneasiness)
Neuropathy peripheral (surface nerve damage)
Plasmacytoma (neoplasm of plasma cells (usually in bone marrow))
Platelet count decreased
Pyrexia (fever)

What are the common drug interactions of Pramine and Valacyclovir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Linear iga disease (a rare, idiopathic or drug-induced autoimmune blistering disease of skin)

20-29:

Nasal disorder (diseases of nose)

30-39:

n/a

40-49:

Dehydration (dryness resulting from the removal of water)

50-59:

Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Arthralgia (joint pain)
Chest pain
Colonic pseudo-obstruction (severe impairment in the ability of the intestines to push food through)
Contusion (a type of hematoma of tissue in which capillaries)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Epicondylitis (tennis elbow)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

60+:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Completed suicide (act of taking one's own life)
Concussion (short loss of normal brain function in response to a head injury)
Contusion (a type of hematoma of tissue in which capillaries)
Drug ineffective
Dry eye (lack of adequate tears)
Dyspnoea (difficult or laboured respiration)
Facial bones fracture (bone fracture of face)
Fall
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 20.45%
Herpes Simplex (herpes simplex is a common viral infection): 5 people, 11.36%
Pain: 4 people, 9.09%
High Blood Pressure: 4 people, 9.09%
Diffuse Large B-Cell Lymphoma Stage Iv (cancer of b cells, a type of white blood cell-stage iv): 4 people, 9.09%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 9.09%
Breast Cancer: 4 people, 9.09%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 3 people, 6.82%
Hypersensitivity: 3 people, 6.82%
Depression: 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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