Prandin and Isosorbide mononitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prandin (repaglinide) and Isosorbide mononitrate (isosorbide mononitrate). Common drug interactions include chronic kidney disease among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Prandin and Isosorbide mononitrate. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Prandin?

Prandin has active ingredients of repaglinide. It is often used in diabetes. eHealthMe is studying from 4,680 Prandin users. Check the latest studies of Prandin.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.



On Jul, 21, 2026

29 people who take Prandin and Isosorbide mononitrate together, and have interactions are studied.

Prandin and Isosorbide mononitrate drug interactions.

What are the common drug interactions of Prandin and Isosorbide Mononitrate, by gender? *:

female:

  1. Chronic kidney disease
  2. Renal tubular necrosis (death of kidney tubules)
  3. Arthralgia (joint pain)
  4. Asthenia (weakness)
  5. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
  6. Dry skin
  7. Dysstasia (difficulty in standing)
  8. Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
  9. Fatigue (feeling of tiredness)
  10. Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)

male:

  1. Anxiety
  2. Cardiac disorder
  3. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  4. Arteriosclerosis (thickening and hardening of arteries)
  5. Cardiac failure congestive
  6. Cardiomyopathy (weakening of the heart muscle)
  7. Chronic kidney disease
  8. Colonic polyp (extra part of colon tissue grow in intestine)
  9. Colonoscopy
  10. Constipation

What are the common drug interactions of Prandin and Isosorbide Mononitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Death

60+:

  1. Anxiety
  2. Cardiac disorder
  3. Asthenia (weakness)
  4. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
  5. Dry skin
  6. Dysstasia (difficulty in standing)
  7. Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
  8. Fatigue (feeling of tiredness)
  9. Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
  10. Hypoaesthesia (reduced sense of touch or sensation)

What are the existing conditions these people have? *

  1. Hyperkalemia (damage to or disease of the kidney): 9 people, 31.03%
  2. High Blood Pressure: 6 people, 20.69%
  3. Multiple Myeloma (cancer of the plasma cells): 5 people, 17.24%
  4. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 17.24%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 13.79%
  6. Insomnia (sleeplessness): 4 people, 13.79%
  7. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 4 people, 13.79%
  8. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 13.79%
  9. Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 10.34%
  10. Laxative Supportive Care: 3 people, 10.34%

* Approximation only. Some reports may have incomplete information.

Do you take Prandin and Isosorbide mononitrate?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Prandin and Isosorbide mononitrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prandin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Isosorbide mononitrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prandin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Isosorbide mononitrate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on repaglinide and isosorbide mononitrate (the active ingredients of Prandin and Isosorbide mononitrate, respectively), and Prandin and Isosorbide mononitrate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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