Prednisone and Nicorette drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prednisone (prednisone) and Nicorette (nicotine polacrilex). Common drug interactions include osteonecrosis among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Prednisone and Nicorette. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Prednisone?

Prednisone has active ingredients of prednisone. It is often used in rheumatoid arthritis. eHealthMe is studying from 636,827 Prednisone users. Check the latest studies of Prednisone.

What is Nicorette?

Nicorette has active ingredients of nicotine polacrilex. It is often used in quit smoking. eHealthMe is studying from 18,484 Nicorette users. Check the latest studies of Nicorette.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

96 people who take Prednisone and Nicorette together, and have interactions are studied.

Prednisone and Nicorette drug interactions.

What are the common drug interactions of Prednisone and Nicorette, by gender? *:

female:

Osteonecrosis (death of bone)
Weight increased
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Pain
Somnolence (a state of near-sleep, a strong desire for sleep)
Diarrhoea
Headache (pain in head)
Hypersensitivity
Nausea (feeling of having an urge to vomit)

male:

Blood pressure increased
Dizziness
Gout (uric acid crystals building up in the body)
Groin pain
Hangover
Infusion site swelling
Intestinal obstruction
Myalgia (muscle pain)
Restlessness (not able to rest)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Prednisone and Nicorette, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abnormal dreams
Agitation (state of anxiety or nervous excitement)
Depression
Psychotic disorder
Sleep disorder
Suicidal ideation
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)
Swelling

30-39:

Burning sensation
Chronic kidney disease
Dermatitis allergic (inflammation of the skin due allergic reaction)
Nausea (feeling of having an urge to vomit)
Peripheral swelling
Pruritus (severe itching of the skin)
Renal failure (kidney dysfunction)

40-49:

Depression
Arthralgia (joint pain)
Hypersensitivity
Hypotension (abnormally low blood pressure)
Daydreaming
Irritability
Nightmare (unpleasant dream)
Pain
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Poor quality sleep

50-59:

Infusion site swelling
Intestinal obstruction
Loss of consciousness
Myalgia (muscle pain)
Restlessness (not able to rest)
Energy increased
Testicular mass (mass on testes)
Testicular neoplasm (testes tumour)
Therapeutic response unexpected
Vitamin b12 deficiency

60+:

Osteonecrosis (death of bone)
Pneumonia
Blood pressure systolic increased
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
C-reactive protein increased
Dehydration (dryness resulting from the removal of water)
Diplopia (double vision)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Eye discharge

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 19 people, 19.79%
Pain: 9 people, 9.38%
High Blood Pressure: 8 people, 8.33%
Asthma: 8 people, 8.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 7.29%
Osteoporosis (bones weak and more likely to break): 6 people, 6.25%
Diabetes: 6 people, 6.25%
Depression: 6 people, 6.25%
Stress And Anxiety: 5 people, 5.21%
Nausea (feeling of having an urge to vomit): 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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