Premarin and Combigan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Premarin (estrogens, conjugated) and Combigan (brimonidine tartrate; timolol maleate). Common drug interactions include ocular hyperaemia among females.

The phase IV clinical study analyzes what interactions people have when they take Premarin and Combigan. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Combigan?

Combigan has active ingredients of brimonidine tartrate; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 7,810 Combigan users. Check the latest studies of Combigan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

41 people who take Premarin and Combigan together, and have interactions are studied.

Premarin and Combigan drug interactions.

What are the common drug interactions of Premarin and Combigan, by gender? *:

female:

Ocular hyperaemia (an abnormally large amount of blood in eye)
Eye irritation
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blindness
Bone pain
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Corneal degeneration (abnormal deposition of substances in the transparent front part of the eye)
Corneal disorder
Corneal opacity (scarring or clouding of the cornea)

male:

n/a

What are the common drug interactions of Premarin and Combigan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Emotional distress
Gout (uric acid crystals building up in the body)
Hot flush (sudden feelings of heat)
Migraine (headache)
Nasopharyngitis (inflammation of the nasopharynx)

60+:

Eye irritation
Ocular hyperaemia (an abnormally large amount of blood in eye)
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Corneal degeneration (abnormal deposition of substances in the transparent front part of the eye)
Corneal disorder
Corneal opacity (scarring or clouding of the cornea)
Death
Fall
Headache (pain in head)
Injury

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 10 people, 24.39%
Drowsiness: 5 people, 12.20%
Stress And Anxiety: 4 people, 9.76%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 9.76%
Dry Eyes (lack of adequate tears): 4 people, 9.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 9.76%
Pain: 3 people, 7.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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